...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>PLOS Neglected Tropical Diseases >A Biomphalaria glabrata peptide that stimulates significant behaviour modifications in aquatic free-living Schistosoma mansoni miracidia
【24h】

A Biomphalaria glabrata peptide that stimulates significant behaviour modifications in aquatic free-living Schistosoma mansoni miracidia

机译：一种可刺激水生自由血曼氏血吸虫miracidia行为显着改变的Biomphalaria glabrata肽

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Author summary In aquatic environments, where the vast majority of animals live in darkness, key relationships are often formed and maintained by chemical communication (including smell and taste). Parasites with an aquatic life phase rely on an exquisite sense of chemosensation to detect host biomolecules (kairomones), allowing them to locate and infect their host. Our study identifies the first kairomone released by the freshwater gastropod snail Biomphalaria glabrata, an intermediate host for the helminth blood fluke parasite Schistosoma mansoni. This is a key aspect of the S. mansoni life-cycle that ultimately leads to human infection, causing the disease schistosomiasis (or bilharzia), which is considered the most devastating human helminth infection in terms of global morbidity and mortality. The kairomone we identify is a peptide that does not appear to share any similarity with any other known animal peptide. This information will be helpful as we explore methods to interrupt parasite infection, and therefore break the cycle of infection that causes a major human disease.
机译：作者摘要在水生环境中，绝大多数动物生活在黑暗中，关键的关系通常通过化学交流（包括气味和味道）形成和维持。具有水生生命阶段的寄生虫依赖于精巧的化学感觉来检测宿主生物分子（海洛酮），从而使它们能够定位并感染宿主。我们的研究确定了淡水腹足类蜗牛Biomphalaria glabrata释放的第一种海洛酮，这是蠕虫血吸虫寄生虫曼氏血吸虫的中间宿主。这是曼氏链球菌生命周期的关键方面，最终导致人类感染，导致血吸虫病（或血吸虫病），就全球发病率和死亡率而言，血吸虫病被认为是最具破坏性的人类蠕虫感染。我们鉴定出的海洛酮是一种似乎与任何其他已知动物肽没有任何相似性的肽。当我们探索中断寄生虫感染的方法时，这些信息将很有帮助，从而打破导致重大人类疾病的感染周期。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号