Crovirin, a Snake Venom Cysteine-Rich Secretory Protein (CRISP) with Promising Activity against Trypanosomes and Leishmania

Camila M. Adade; Ana Lúcia O. Carvalho; Marcelo A. Tomaz; Tatiana F. R. Costa; Joseane L. Godinho; Paulo A. Melo; Ana Paula C. A. Lima; Juliany C. F. Rodrigues; Russolina B. Zingali; Tha?s Souto-Padrón

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Crovirin, a Snake Venom Cysteine-Rich Secretory Protein (CRISP) with Promising Activity against Trypanosomes and Leishmania

机译：Crovirin，一种蛇毒富含半胱氨酸的分泌蛋白（CRISP），对锥虫和利什曼原虫有良好的活性

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Background The neglected human diseases caused by trypanosomatids are currently treated with toxic therapy with limited efficacy. In search for novel anti-trypanosomatid agents, we showed previously that the Crotalus viridis viridis (Cvv) snake venom was active against infective forms of Trypanosoma cruzi. Here, we describe the purification of crovirin, a cysteine-rich secretory protein (CRISP) from Cvv venom with promising activity against trypanosomes and Leishmania.

机译：背景技术由锥虫引起的被忽视的人类疾病目前以毒性疗法治疗，疗效有限。在寻找新型抗锥虫的药物时，我们先前证明了响尾蛇蛇毒（Cvv）蛇毒对克氏锥虫的感染形式具有活性。在这里，我们描述了从Cvv毒液中纯化的crovirin，一种富含半胱氨酸的分泌蛋白（CRISP），具有针对锥虫和利什曼原虫的有希望的活性。

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《PLOS Neglected Tropical Diseases》 |2014年第10期|共9页
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Camila M. Adade; Ana Lúcia O. Carvalho; Marcelo A. Tomaz; Tatiana F. R. Costa; Joseane L. Godinho; Paulo A. Melo; Ana Paula C. A. Lima; Juliany C. F. Rodrigues; Russolina B. Zingali; Tha?s Souto-Padrón;
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1. Wide distribution of cysteine-rich secretory proteins in snake venoms: Isolation and cloning of novel snake venom cysteine-rich secretory proteins [J] . Yamazaki Y., Hyodo F., Morita T. Archives of Biochemistry and Biophysics . 2003,第1期

机译：富含半胱氨酸的分泌蛋白在蛇毒中的广泛分布：新型蛇毒富含半胱氨酸的分泌蛋白的分离和克隆
2. Cysteine-Rich Secretory Proteins (CRISPs) from Venomous Snakes: An Overview of the Functional Diversity in a Large and Underappreciated Superfamily [J] . International journal of applied mechanics . 2020,第3期

机译：富含毒蛇的半胱氨酸分泌蛋白（CRISPS）：概述大而低于覆富的超家族的功能多样性
3. The isolation and characterization of a new snake venom cysteine-rich secretory protein (svCRiSP) from the venom of the Southern Pacific rattlesnake and its effect on vascular permeability [J] . Suntravat Montamas, Cromer Walter E., Marquez Jessenia, Toxicon: An International Journal Devoted to the Exchange of Knowledge on the Poisons Derived from Animals, Plants and Microorganisms . 2019,第期

机译：从南太平洋鹿角毒液的毒液中富含蛇毒性半胱氨酸的分泌蛋白（SVCRISP）的分离与表征及其对血管渗透性的影响
4. Characterization of bioactive peptides from snake venoms by LC-MS coupled to bioactivity assessment via at-line nanofractionation [C] . Marija Mladi, Janaki Iyer, Martine Smit, International Mass Spectrometry Conference . 2014

机译：LC-MS通过在纳米纳米分接收中通过LC-MS与生物活性评估的生物活性肽的表征
5. Characterization of biological activities and toxicity of synthetic peptides derived from Parotid Secretory Protein (PSP) [D] . Shelar, Anuradha P. 2009

机译：腮腺分泌蛋白（PSP）合成肽的生物活性和毒性表征
6. Crovirin a Snake Venom Cysteine-Rich Secretory Protein (CRISP) with Promising Activity against Trypanosomes and Leishmania [O] . Camila M. Adade, Ana Lúcia O. Carvalho, Marcelo A. Tomaz, 2014

机译：Crovirin蛇毒富含半胱氨酸的分泌蛋白（CRISP）对锥虫和利什曼原虫有良好的活性
7. Crovirin, a snake venom cysteine-rich secretory protein (CRISP) with promising activity against Trypanosomes and Leishmania. [O] . Camila M Adade, Ana Lúcia O Carvalho, Marcelo A Tomaz, 2014

机译：克罗维林是一种蛇毒富含半胱氨酸的分泌蛋白（CRIsp），具有很强的抗锥虫和利什曼原虫的活性。
8. Snake Venom Components and Their Cross Reactivity: A Short Review [R] . Berger, B. J., Bhatti, A. R. 1988

机译：蛇毒成分及其交叉反应性：简短回顾

Crovirin, a Snake Venom Cysteine-Rich Secretory Protein (CRISP) with Promising Activity against Trypanosomes and Leishmania

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