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首页> 外文期刊>PLOS Neglected Tropical Diseases >Alterations in Peripheral Blood B Cell Subsets and Dynamics of B Cell Responses during Human Schistosomiasis
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Alterations in Peripheral Blood B Cell Subsets and Dynamics of B Cell Responses during Human Schistosomiasis

机译：人类血吸虫病期间外周血B细胞亚群的变化和B细胞反应的动力学

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Antibody responses are thought to play an important role in control of Schistosoma infections, yet little is known about the phenotype and function of B cells in human schistosomiasis. We set out to characterize B cell subsets and B cell responses to B cell receptor and Toll-like receptor 9 stimulation in Gabonese schoolchildren with Schistosoma haematobium infection. Frequencies of memory B cell (MBC) subsets were increased, whereas naive B cell frequencies were reduced in the schistosome-infected group. At the functional level, isolated B cells from schistosome-infected children showed higher expression of the activation marker CD23 upon stimulation, but lower proliferation and TNF-α production. Importantly, 6-months after 3 rounds of praziquantel treatment, frequencies of naive B cells were increased, MBC frequencies were decreased and with the exception of TNF-α production, B cell responsiveness was restored to what was seen in uninfected children. These data show that S. haematobium infection leads to significant changes in the B cell compartment, both at the phenotypic and functional level.
机译：人们认为抗体反应在控制血吸虫感染中起着重要作用，但是关于人类血吸虫病中B细胞的表型和功能知之甚少。我们着手表征血吸虫血吸虫感染的加蓬小学生的B细胞亚群和B细胞对B细胞受体和Toll样受体9刺激的反应。血吸虫感染组中记忆B细胞（MBC）子集的频率增加，而幼稚B细胞频率降低。在功能水平上，受血吸虫感染的儿童分离出的B细胞在刺激后显示出活化标记CD23的较高表达，但其增殖和TNF-α的产生却较低。重要的是，经过3轮吡喹酮治疗6个月后，幼稚B细胞的频率增加，MBC频率降低，除TNF-α产生外，B细胞反应性恢复到未感染儿童的水平。这些数据表明，在表型和功能水平上，嗜血链球菌感染都会导致B细胞区室的显着变化。

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