Antileishmanial Activity of the Estrogen Receptor Modulator Raloxifene

Juliana Q. Reim?o; Danilo C. Miguel; Noemi N. Taniwaki; Cristiana T. Trinconi; Jenicer K. U. Yokoyama-Yasunaka; Silvia R. B. Uliana

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Antileishmanial Activity of the Estrogen Receptor Modulator Raloxifene

机译：雌激素受体调节剂雷洛昔芬的抗leishmanial活动

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Background The treatment of leishmaniasis relies mostly on parenteral drugs with potentially serious adverse effects. Additionally, parasite resistance in the treatment of leishmaniasis has been demonstrated for the majority of drugs available, making the search for more effective and less toxic drugs and treatment regimens a priority for the control of leishmaniasis. The aims of this study were to evaluate the antileishmanial activity of raloxifene in vitro and in vivo and to investigate its mechanism of action against Leishmania amazonensis.

机译：背景技术利什曼病的治疗主要依赖于肠胃外药物，具有潜在的严重不良作用。另外，已经证明大多数可用药物对治疗利什曼病的寄生虫耐药性，使得寻找更有效和毒性较小的药物和治疗方案成为控制利什曼病的优先事项。这项研究的目的是评估雷洛昔芬在体内和体外的抗菌活性，并研究其对亚马逊利什曼原虫的作用机理。

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《PLOS Neglected Tropical Diseases》 |2014年第5期|共11页
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Juliana Q. Reim?o; Danilo C. Miguel; Noemi N. Taniwaki; Cristiana T. Trinconi; Jenicer K. U. Yokoyama-Yasunaka; Silvia R. B. Uliana;
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1. The Selective Estrogen Receptor Modulator Raloxifene Regulates Arginine-Vasopressin Gene Expression in Human Female Neuroblastoma Cells Through G Protein-Coupled Estrogen Receptor and ERK Signaling [J] . Grassi Daniela, Ghorbanpoor Samar, Acaz-Fonseca Estefania, Endocrinology . 2015,第10期

机译：选择性雌激素受体调节剂雷洛昔芬通过G蛋白偶联的雌激素受体和ERK信号调节人类女性成神经细胞瘤细胞中精氨酸-加压素基因的表达。
2. Structure-Activity Relationships for a Family of Benzothiophene Selective Estrogen Receptor Modulators Including Raloxifene and Arzoxifene [J] . Cassia R.Overk, Kuan-Wei Peng, Rezene T.Asghodom ChemMedChem . 2007,第10期

机译：苯并噻吩选择性雌激素受体调节剂，包括雷洛昔芬和Arzoxifene家族的结构-活性关系。
3. Hypocholesterolemic activity of raloxifene (LY139481): pharmacological characterization as a selective estrogen receptor modulator. [J] . Kauffman RF, Bensch WR, Roudebush RE, The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics . 1997,第1期

机译：雷洛昔芬的降胆固醇活性（LY139481）：作为选择性雌激素受体调节剂的药理学表征。
4. Estrogen Receptors and Selective Estrogen Receptor Modulators in Bladder Cancer [C] . Kristi Hoffman, Carolyn L. Smith ^dgt, Baylor College of Medicine, Genitourinary Cancers Symposium . 2012

机译：膀胱癌中雌激素受体和选择性雌激素受体调节剂
5. The effects of the selective estrogen receptor modulators MPP and raloxifene in normal and cancerous human and murine uterine tissue. [D] . Davis, Angela Marie. 2007

机译：选择性雌激素受体调节剂MPP和雷洛昔芬在正常和癌变的人和鼠子宫组织中的作用。
6. Antileishmanial Activity of the Estrogen Receptor Modulator Raloxifene [O] . Juliana Q. Reimão, Danilo C. Miguel, Noemi N. Taniwaki, 2014

机译：雌激素受体调节剂雷洛昔芬的抗leishmanial活动
7. Antileishmanial Activity Of The Estrogen Receptor Modulator Raloxifene [O] . Reimao J.Q., Miguel D.C., Taniwaki N.N., 2015

机译：雌激素受体调节剂雷洛昔芬的抗leishmanial活动
8. Solid Phase Combinatorial Approach to Estradiol Tamoxifen/Raloxifene Hybrids: Novel Chemotherapeutic/Prophylactic Selective Estrogen Receptor Modulators [R] . Hanson, R. N. 2002

机译：雌二醇他莫昔芬/雷洛昔芬杂交的固相组合方法：新型化疗/预防性选择性雌激素受体调节剂

Antileishmanial Activity of the Estrogen Receptor Modulator Raloxifene

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