...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>PLoS One >A Salmon Protein Hydrolysate Exerts Lipid-Independent Anti-Atherosclerotic Activity in ApoE-Deficient Mice
【24h】

A Salmon Protein Hydrolysate Exerts Lipid-Independent Anti-Atherosclerotic Activity in ApoE-Deficient Mice

机译：鲑鱼蛋白水解物在ApoE缺陷小鼠中表现出脂质独立的抗动脉粥样硬化活性。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Fish consumption is considered health beneficial as it decreases cardiovascular disease (CVD)-risk through effects on plasma lipids and inflammation. We investigated a salmon protein hydrolysate (SPH) that is hypothesized to influence lipid metabolism and to have anti-atherosclerotic and anti-inflammatory properties. 24 female apolipoprotein (apo) E−/− mice were divided into two groups and fed a high-fat diet with or without 5% (w/w) SPH for 12 weeks. The atherosclerotic plaque area in aortic sinus and arch, plasma lipid profile, fatty acid composition, hepatic enzyme activities and gene expression were determined. A significantly reduced atherosclerotic plaque area in the aortic arch and aortic sinus was found in the 12 apoE−/− mice fed 5% SPH for 12 weeks compared to the 12 casein-fed control mice. Immunohistochemical characterization of atherosclerotic lesions in aortic sinus displayed no differences in plaque composition between mice fed SPH compared to controls. However, reduced mRNA level of Icam1 in the aortic arch was found. The plasma content of arachidonic acid (C20∶4n-6) and oleic acid (C18∶1n-9) were increased and decreased, respectively. SPH-feeding decreased the plasma concentration of IL-1β, IL-6, TNF-α and GM-CSF, whereas plasma cholesterol and triacylglycerols (TAG) were unchanged, accompanied by unchanged mitochondrial fatty acid oxidation and acyl-CoA:cholesterol acyltransferase (ACAT)-activity. These data show that a 5% (w/w) SPH diet reduces atherosclerosis in apoE−/− mice and attenuate risk factors related to atherosclerotic disorders by acting both at vascular and systemic levels, and not directly related to changes in plasma lipids or fatty acids.
机译：食用鱼被认为对健康有益，因为它通过对血脂和炎症的影响来降低心血管疾病（CVD）的风险。我们研究了鲑鱼蛋白水解物（SPH），该蛋白被认为会影响脂质代谢并具有抗动脉粥样硬化和抗炎特性。将24只雌性载脂蛋白（apo）E-/-小鼠分为两组，并在高脂饮食中添加或不添加5％（w / w）SPH，持续12周。测定主动脉窦和弓的动脉粥样硬化斑块面积，血脂谱，脂肪酸组成，肝酶活性和基因表达。与12只酪蛋白喂养的对照小鼠相比，在喂食5％SPH 12周的12只apoE-/-小鼠中，发现主动脉弓和主动脉窦的动脉粥样硬化斑块面积明显减少。与对照组相比，用SPH喂养的小鼠之间主动脉窦动脉粥样硬化病变的免疫组织化学表征显示斑块组成没有差异。但是，发现主动脉弓Icam1的mRNA水平降低。血浆花生四烯酸（C20∶4n-6）和油酸（C18∶1n-9）的含量分别升高和降低。 SPH喂养降低了血浆中IL-1β，IL-6，TNF-α和GM-CSF的浓度，而血浆胆固醇和三酰甘油（TAG）不变，伴随着线粒体脂肪酸氧化和酰基-CoA：胆固醇酰基转移酶（ ACAT）-活动。这些数据表明，5％（w / w）SPH饮食可通过在血管和全身水平上起作用而与apoE-/-小鼠减少动脉粥样硬化，并减轻与动脉粥样硬化疾病相关的危险因素，而与血浆脂质或脂肪的变化没有直接关系酸。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号