CD4 T Cell-Derived IFN-γ Plays a Minimal Role in Control of Pulmonary Mycobacterium tuberculosis Infection and Must Be Actively Repressed by PD-1 to Prevent Lethal Disease

Arlene H. Sharpe; Daniel L. Barber; Howard A. Young; Keith D. Kauffman; Michelle A. Sallin; Shunsuke Sakai; Vitaly V. Ganusov

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CD4 T Cell-Derived IFN-γ Plays a Minimal Role in Control of Pulmonary Mycobacterium tuberculosis Infection and Must Be Actively Repressed by PD-1 to Prevent Lethal Disease

机译：CD4 T细胞衍生的IFN-γ在控制肺结核分枝杆菌感染中起着最小的作用，必须被PD-1积极抑制以预防致死性疾病

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《PLoS Pathogens》 |2016年第5期|共页
作者
Arlene H. Sharpe; Daniel L. Barber; Howard A. Young; Keith D. Kauffman; Michelle A. Sallin; Shunsuke Sakai; Vitaly V. Ganusov;
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1. NK Cells Respond to Pulmonary Infection with Mycobacterium tuberculosis, but Play a Minimal Role in Protection [J] . Ana Paula Junqueira-Kipnis, Andre Kipnis, Amanda Jamieson, The journal of immunology . 2003,第11期

机译：NK细胞对结核分枝杆菌的肺部感染有反应，但在保护中起的作用很小
2. CD4+ T Cells Mediate IFN-γ-Independent Control of Mycobacterium tuberculosis Infection Both In Vitro and In Vivo [J] . Siobhán C. Cowley, Karen L. Elkins The journal of immunology . 2003,第9期

机译：CD4 + T细胞在体内和体外介导结核分枝杆菌感染的IFN-γ非依赖性控制
3. Combined Expression of IFN-γ, IL-17, and IL-4 mRNA by Recall PBMCs Moderately Discriminates Active Tuberculosis from Latent Mycobacterium tuberculosis Infection in Patients with Miscellaneous Inflammatory Underlying Conditions [J] . Laura E. Savolainen, Anu Kantele, Aija Knuuttila, Frontiers in Immunology . 2016,第12期

机译：召回PBMC联合表达IFN-γ，IL-17和IL-4 mRNA可将活动性结核病与其他潜在炎症性疾病患者的潜在结核分枝杆菌感染区分开。
4. Mycobacterium tuberculosis Antigen-Specific IL-2R and IP-10 Expression Changes in Chronic Obstructive Pulmonary Disease Patients with in Latent Tuberculosis Infection [C] . Sungyong Bong, Sunghyun Kim, Joo Hwan Hwang, International Molecular Medicine Tri-Conference. . 2016

机译：结核分枝杆菌抗原特异性IL-2R和IP-10表达变化慢性阻塞性肺病患者潜在结核病感染
5. Effective combination of syngeneic HCT with CRCL vaccination to treat BCR-ABL+ leukemia, and, CD4+CD25+FOXP3+ regulatory T cells suppress Mycobacterium tuberculosis immunity in patients with active disease. [D] . Chen, Xinchun. 2006

机译：同基因HCT与CRCL疫苗的有效结合可治疗BCR-ABL +白血病，CD4 + CD25 + FOXP3 +调节性T细胞可抑制活动性疾病患者的结核分枝杆菌免疫力。
6. CD4 T Cell-Derived IFN-γ Plays a Minimal Role in Control of Pulmonary Mycobacterium tuberculosis Infection and Must Be Actively Repressed by PD-1 to Prevent Lethal Disease [O] . Shunsuke Sakai, Keith D. Kauffman, Michelle A. Sallin, 2016

机译：CD4 T细胞衍生的IFN-γ在控制肺结核分枝杆菌感染中起着最小的作用必须被PD-1积极抑制以预防致死性疾病
7. CD4 T Cell-Derived IFN-γ Plays a Minimal Role in Control of Pulmonary Mycobacterium tuberculosis Infection and Must Be Actively Repressed by PD-1 to Prevent Lethal Disease. [O] . Shunsuke Sakai, Keith D Kauffman, Michelle A Sallin, 2016

机译：CD4 T细胞衍生的IFN-γ在控制肺结核分枝杆菌感染中发挥最小作用，并且必须被pD-1主动抑制以预防致死性疾病。

CD4 T Cell-Derived IFN-γ Plays a Minimal Role in Control of Pulmonary Mycobacterium tuberculosis Infection and Must Be Actively Repressed by PD-1 to Prevent Lethal Disease

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