Variability in Dengue Titer Estimates from Plaque Reduction Neutralization Tests Poses a Challenge to Epidemiological Studies and Vaccine Development

Henrik Salje; Isabel Rodríguez-Barraquer; Kaitlin Rainwater-Lovett; Ananda Nisalak; Butsaya Thaisomboonsuk; Stephen J. Thomas; Stefan Fernandez; Richard G. Jarman; In-Kyu Yoon; Derek A. T. Cummings

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Variability in Dengue Titer Estimates from Plaque Reduction Neutralization Tests Poses a Challenge to Epidemiological Studies and Vaccine Development

机译：斑块减少中和测试中登革热滴度估计值的变化对流行病学研究和疫苗开发构成了挑战

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Background Accurate determination of neutralization antibody titers supports epidemiological studies of dengue virus transmission and vaccine trials. Neutralization titers measured using the plaque reduction neutralization test (PRNT) are believed to provide a key measure of immunity to dengue viruses, however, the assay's variability is poorly understood, making it difficult to interpret the significance of any assay reading. In addition there is limited standardization of the neutralization evaluation point or statistical model used to estimate titers across laboratories, with little understanding of the optimum approach.

机译：背景技术准确测定中和抗体滴度可支持登革病毒传播和疫苗试验的流行病学研究。据信使用噬斑减少中和试验（PRNT）测量的中和效价是对登革热病毒免疫力的关键指标，但是，该方法的可变性了解甚少，因此很难解释任何方法读数的重要性。此外，用于评估整个实验室效价的中和评估点或统计模型的标准化有限，对最佳方法的了解很少。

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《PLOS Neglected Tropical Diseases》 |2014年第6期|共10页
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Henrik Salje; Isabel Rodríguez-Barraquer; Kaitlin Rainwater-Lovett; Ananda Nisalak; Butsaya Thaisomboonsuk; Stephen J. Thomas; Stefan Fernandez; Richard G. Jarman; In-Kyu Yoon; Derek A. T. Cummings;
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1. Variability in Dengue Titer Estimates from Plaque Reduction Neutralization Tests Poses a Challenge to Epidemiological Studies and Vaccine Development [J] . Henrik Salje, Isabel Rodríguez-Barraquer, Kaitlin Rainwater-Lovett, PLOS Neglected Tropical Diseases . 2014,第6期

机译：斑块减少中和测试中登革热滴度估计值的变化对流行病学研究和疫苗开发构成了挑战
2. Optimization and validation of a plaque reduction neutralization test for the detection of neutralizing antibodies to four serotypes of dengue virus used in support of dengue vaccine development [J] . TimiryasovaT.M., BonaparteM.I., LuoP., The American Journal of Tropical Medicine and Hygiene . 2013,第5期

机译：优化和验证噬斑减少中和试验，以检测用于支持登革热疫苗开发的四种血清型登革热病毒的中和抗体
3. Discrepancy in Dengue Virus Neutralizing Antibody Titers between Plaque Reduction Neutralizing Tests with Fcγ Receptor (FcγR)-Negative and FcγR-Expressing BHK-21 Cells [J] . Meng Ling Moi, Chang-Kweng Lim, Akira Kotaki, Clinical and vaccine immunology: CVI . 2010,第3期

机译：Fcγ受体（FcγR）阴性和表达FcγR的BHK-21细胞在噬斑减少中和试验之间登革热病毒中和抗体滴度的差异
4. DEVELOPMENTS IN DWDM SYSTEMS AND THE CHALLENGES THEY POSE TO WDM TEST EQUIPMENT [C] . L. Mason, S. Vigot, E. Gagnon NFOEC '99;Annual national fiber optic engineers conference . 1999

机译：DWDM系统的发展及其对WDM测试设备的挑战
5. Validation of Chimera Viruses in Plaque Reduction Neutralization Tests for Arboviral Disease Diagnostics [D] . Boykin, Jasmine. 2017

机译：嵌合体病毒在噬菌斑减少中和试验中对虫媒病毒诊断的验证
6. Variability in Dengue Titer Estimates from Plaque Reduction Neutralization Tests Poses a Challenge to Epidemiological Studies and Vaccine Development [O] . Henrik Salje, Isabel Rodríguez-Barraquer, Kaitlin Rainwater-Lovett, 2014

机译：减少斑块的中和试验得出的登革热滴度估计值的变化对流行病学研究和疫苗开发构成了挑战
7. Variability in dengue titer estimates from plaque reduction neutralization tests poses a challenge to epidemiological studies and vaccine development. [O] . Henrik Salje, Isabel Rodríguez-Barraquer, Kaitlin Rainwater-Lovett, 2014

机译：来自斑块减少中和试验的登革热滴度估计值的变化对流行病学研究和疫苗开发提出了挑战。

Variability in Dengue Titer Estimates from Plaque Reduction Neutralization Tests Poses a Challenge to Epidemiological Studies and Vaccine Development

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