• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>PLOS Neglected Tropical Diseases >Development of Peptide-Based Lineage-Specific Serology for Chronic Chagas Disease: Geographical and Clinical Distribution of Epitope Recognition
【24h】

Development of Peptide-Based Lineage-Specific Serology for Chronic Chagas Disease: Geographical and Clinical Distribution of Epitope Recognition

机译：慢性Chagas疾病的基于肽的谱系特异性血清学的发展：抗原决定簇识别的地理和临床分布

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background Chagas disease, caused by infection with the protozoan Trypanosoma cruzi, remains a serious public health issue in Latin America. Genetically diverse, the species is sub-divided into six lineages, known as TcI–TcVI, which have disparate geographical and ecological distributions. TcII, TcV, and TcVI are associated with severe human disease in the Southern Cone countries, whereas TcI is associated with cardiomyopathy north of the Amazon. T. cruzi persists as a chronic infection, with cardiac and/or gastrointestinal symptoms developing years or decades after initial infection. Identifying an individual's history of T. cruzi lineage infection directly by genotyping of the parasite is complicated by the low parasitaemia and sequestration in the host tissues.
机译：背景技术由原生动物克氏锥虫感染引起的南美锥虫病仍然是拉丁美洲的严重公共卫生问题。从遗传学上讲，该物种可细分为六个世系，称为TcI–TcVI，它们具有不同的地理和生态分布。 TcII，TcV和TcVI与南锥体国家的严重人类疾病有关，而TcI与亚马逊河北部的心肌病有关。克鲁氏锥虫作为一种慢性感染持续存在，在初次感染数年或数十年后出现心脏和/或胃肠道症状。通过寄生虫的基因分型直接鉴定一个人的克氏锥虫谱系感染的历史，由于寄生虫血症低和宿主组织中的螯合而变得复杂。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号