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首页> 外文期刊>PLOS Neglected Tropical Diseases >A Sero-epidemiological Study of Arboviral Fevers in Djibouti, Horn of Africa
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A Sero-epidemiological Study of Arboviral Fevers in Djibouti, Horn of Africa

机译：非洲之角吉布提的虫媒血清热流行病学研究

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Arboviral infections have repeatedly been reported in the republic of Djibouti, consistent with the fact that essential vectors for arboviral diseases are endemic in the region. However, there is a limited recent information regarding arbovirus circulation, and the associated risk predictors to human exposure are largely unknown. We performed, from November 2010 to February 2011 in the Djibouti city general population, a cross-sectional ELISA and sero-neutralisation-based sero-epidemiological analysis nested in a household cohort, which investigated the arboviral infection prevalence and risk factors, stratified by their vectors of transmission. Antibodies to dengue virus (21.8%) were the most frequent. Determinants of infection identified by multivariate analysis pointed to sociological and environmental exposure to the bite of Aedes mosquitoes. The population was broadly na?ve against Chikungunya (2.6%) with risk factors mostly shared with dengue. The detection of limited virus circulation was followed by a significant Chikungunya outbreak a few months after our study. Antibodies to West Nile virus were infrequent (0.6%), but the distribution of cases faithfully followed previous mapping of infected Culex mosquitoes. The seroprevalence of Rift valley fever virus was 2.2%, and non-arboviral transmission was suggested. Finally, the study indicated the circulation of Toscana-related viruses (3.7%), and a limited number of cases suggested infection by tick-borne encephalitis or Alkhumra related viruses, which deserve further investigations to identify the viruses and vectors implicated. Overall, most of the arboviral cases' predictors were statistically best described by the individuals' housing space and neighborhood environmental characteristics, which correlated with the ecological actors of their respective transmission vectors' survival in the local niche. This study has demonstrated autochthonous arboviral circulations in the republic of Djibouti, and provides an epidemiological inventory, with useful findings for risk mapping and future prevention and control programs.
机译：吉布提共和国已多次报道虫媒病毒感染，这与该地区流行的虫媒病毒疾病的重要媒介是一致的。但是，关于虫媒病毒传播的最新信息有限，而且人类暴露的相关风险预测因子在很大程度上尚不清楚。我们于2010年11月至2011年2月在吉布提市的普通人群中进行了横断面ELISA和基于血清中和的血清流行病学分析，该研究嵌套在一个家庭队列中，该调查研究了病毒的流行程度和危险因素，按其分类传播载体。登革热病毒抗体（21.8％）是最常见的。通过多因素分析确定的感染决定因素表明，蚊子叮咬对社会和环境的影响。人口对基孔肯雅犬的态度尚不成熟（占2.6％），危险因素大多与登革热相同。在我们的研究几个月后，发现病毒传播受限，随后出现了严重的基孔肯雅热疫情。西尼罗河病毒的抗体很少（占0.6％），但如实地按照先前绘制的被感染库克斯蚊子的图谱进行分布。裂谷热病毒的血清阳性率为2.2％，提示非虫媒病毒传播。最后，该研究表明了托斯卡纳相关病毒的流行（3.7％），并且少数病例表明被tick传脑炎或Alkhumra相关病毒感染，值得进一步研究以鉴定所涉及的病毒和载体。总体而言，大多数个体病毒病例的预测因素在统计学上可以通过个体的居住空间和邻里环境特征来最好地描述，这与他们各自的传播媒介在当地环境中生存的生态因素相关。这项研究证明了吉布提共和国的虫媒病毒循环，并提供了流行病学清单，并为风险定位和未来的预防和控制计划提供了有用的发现。

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