A Thrombomodulin Mutation that Impairs Active Protein C Generation Is Detrimental in Severe Pneumonia-Derived Gram-Negative Sepsis (Melioidosis)

Liesbeth M. Kager; W. Joost Wiersinga; Joris J. T. H. Roelofs; Onno J. de Boer; Hartmut Weiler; Cornelis van t Veer; Tom van der Poll

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A Thrombomodulin Mutation that Impairs Active Protein C Generation Is Detrimental in Severe Pneumonia-Derived Gram-Negative Sepsis (Melioidosis)

机译：严重影响肺炎衍生的革兰氏阴性败血症（类eli虫病）的损害活性蛋白C生成的血栓调节蛋白突变是有害的。

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Background During severe (pneumo)sepsis inflammatory and coagulation pathways become activated as part of the host immune response. Thrombomodulin (TM) is involved in a range of host defense mechanisms during infection and plays a pivotal role in activation of protein C (PC) into active protein C (APC). APC has both anticoagulant and anti-inflammatory properties. In this study we investigated the effects of impaired TM-mediated APC generation during melioidosis, a common form of community-acquired Gram-negative (pneumo)sepsis in South-East Asia caused by Burkholderia (B.) pseudomallei.

机译：背景在严重的（肺）败血症中，炎症和凝血途径被激活，成为宿主免疫反应的一部分。血栓调节蛋白（TM）参与感染过程中的多种宿主防御机制，并在将蛋白C（PC）活化为活性蛋白C（APC）方面发挥关键作用。 APC同时具有抗凝和抗炎特性。在这项研究中，我们调查了类鼻疽病（TM）介导的APC生成受损的影响，类鼻虫病是假单胞菌（Burkholderia（B.））在东南亚引起的社区获得性革兰氏阴性（肺炎）败血症的常见形式。

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《PLOS Neglected Tropical Diseases》 |2014年第4期|共10页
作者
Liesbeth M. Kager; W. Joost Wiersinga; Joris J. T. H. Roelofs; Onno J. de Boer; Hartmut Weiler; Cornelis van t Veer; Tom van der Poll;
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1. Overexpression of the Endothelial Protein C Receptor Is Detrimental during Pneumonia-Derived Gram-negative Sepsis (Melioidosis) [J] . Liesbeth M. Kager, Marcel Schouten, W. Joost Wiersinga, PLOS Neglected Tropical Diseases . 2013,第7期

机译：肺炎衍生的革兰氏阴性脓毒症（类eli虫病）期间内皮蛋白C受体的过度表达是有害的。
2. Endogenous tissue-type plasminogen activator impairs host defense during severe experimental gram-negative sepsis (melioidosis) [J] . KagerL.M., JoostWiersingaW., RoelofsJ.J.T.H., Critical care medicine . 2012,第7期

机译：内源性组织型纤溶酶原激活剂在严重的实验性革兰氏阴性败血症（类胡i病）期间损害宿主防御能力
3. Thrombocytopenia impairs host defense in gram-negative pneumonia-derived sepsis in mice [J] . de Stoppelaar Sacha F., vant Veer Cornelis, Claushuis Theodora A. M., Blood: The Journal of the American Society of Hematology . 2014,第25期

机译：血小板减少症会损害小鼠革兰氏阴性肺炎败血症的宿主防御能力
4. Relation of heart rate variability to serum levels of C-reactive protein in patients with severe sepsis and septic shock [C] . Papaioannou V.P., Dragoumanis C.D., Pneumatikos I.P. Computers in Cardiology, 2009 . 2009

机译：严重败血症和败血性休克患者心率变异性与血清C反应蛋白水平的关系
5. A Mutation in Cav2.1 Linked to a Severe Neurodevelopmental Disorder Impairs Channel Gating [D] . Tyagi, Sidharth. 2019

机译：与严重的神经发育障碍相关的Cav2.1突变削弱通道门控。
6. A Thrombomodulin Mutation that Impairs Active Protein C Generation Is Detrimental in Severe Pneumonia-Derived Gram-Negative Sepsis (Melioidosis) [O] . Liesbeth M. Kager, W. Joost Wiersinga, Joris J. T. H. Roelofs, 2014

机译：严重影响肺炎衍生的革兰氏阴性脓毒症（M虫病）中损害活性蛋白C生成的血栓调节蛋白突变是有害的。
7. A thrombomodulin mutation that impairs active protein C generation is detrimental in severe pneumonia-derived gram-negative sepsis (melioidosis). [O] . Liesbeth M Kager, W Joost Wiersinga, Joris J T H Roelofs, 2014

机译：损害活性蛋白C产生的血栓调节蛋白突变在严重的肺炎衍生的革兰氏阴性败血症（类鼻疽）中是有害的。
8. Impaired Glucose Flow in Burned Patients with Gram-Negative Sepsis. [R] . Wilmore, D. W., Mason, A. D., Pruitt, B. 1976

机译：革兰氏阴性脓毒症烧伤患者葡萄糖流量受损。

A Thrombomodulin Mutation that Impairs Active Protein C Generation Is Detrimental in Severe Pneumonia-Derived Gram-Negative Sepsis (Melioidosis)

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