...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>PLOS Neglected Tropical Diseases >Multiple Resistances and Complex Mechanisms of Anopheles sinensis Mosquito: A Major Obstacle to Mosquito-Borne Diseases Control and Elimination in China
【24h】

Multiple Resistances and Complex Mechanisms of Anopheles sinensis Mosquito: A Major Obstacle to Mosquito-Borne Diseases Control and Elimination in China

机译：中华按蚊的多重抗性和复杂机制：中国蚊媒疾病控制和消除的主要障碍

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Malaria, dengue fever, and filariasis are three of the most common mosquito-borne diseases worldwide. Malaria and lymphatic filariasis can occur as concomitant human infections while also sharing common mosquito vectors. The overall prevalence and health significance of malaria and filariasis have made them top priorities for global elimination and control programmes. Pyrethroid resistance in anopheline mosquito vectors represents a highly significant problem to malaria control worldwide. Several methods have been proposed to mitigate insecticide resistance, including rotational use of insecticides with different modes of action. Anopheles sinensis, an important malaria and filariasis vector in Southeast Asia, represents an interesting mosquito species for examining the consequences of long-term insecticide rotation use on resistance. We examined insecticide resistance in two An. Sinensis populations from central and southern China against pyrethroids, organochlorines, organophosphates, and carbamates, which are the major classes of insecticides recommended for indoor residual spray. We found that the mosquito populations were highly resistant to the four classes of insecticides. High frequency of kdr mutation was revealed in the central population, whereas no kdr mutation was detected in the southern population. The frequency of G119S mutation in the ace-1 gene was moderate in both populations. The classification and regression trees (CART) statistical analysis found that metabolic detoxification was the most important resistance mechanism, whereas target site insensitivity of L1014 kdr mutation played a less important role. Our results indicate that metabolic detoxification was the dominant mechanism of resistance compared to target site insensitivity, and suggests that long-term rotational use of various insecticides has led An. sinensis to evolve a high insecticide resistance. This study highlights the complex network of mechanisms conferring multiple resistances to chemical insecticides in mosquito vectors and it has important implication for designing and implementing vector resistance management strategies.
机译：疟疾，登革热和丝虫病是全世界三种最常见的蚊媒疾病。疟疾和淋巴丝虫病可以与人类同时感染，也可以与普通蚊子共享。疟疾和丝虫病的总体流行率和健康意义使它们成为全球消灭和控制方案的重中之重。按蚊蚊载体中的拟除虫菊酯抗药性代表了全世界疟疾控制的高度重要的问题。已经提出了几种减轻杀虫剂抗性的方法，包括轮流使用具有不同作用方式的杀虫剂。中华按蚊是东南亚重要的疟疾和丝虫病媒介，代表一种有趣的蚊子，用于研究长期轮换使用杀虫剂对耐药性的影响。我们在两个An中检查了抗药性。来自中国中部和南部的中华民族对拟除虫菊酯，有机氯，有机磷酸盐和氨基甲酸酯类的推荐是室内残留喷雾剂的主要杀虫剂。我们发现蚊子种群对四类杀虫剂具有高度抵抗力。在中心人群中发现了高频率的kdr突变，而在南部人群中未发现kdr突变。 ace-1基因中G119S突变的频率在两个人群中均中等。分类和回归树（CART）统计分析发现，代谢排毒是最重要的抗药性机制，而L1014 kdr突变的靶位点不敏感性作用不那么重要。我们的结果表明，与目标部位不敏感相比，代谢排毒是抵抗力的主要机制，并表明长期使用各种杀虫剂导致了An。中华绒螯蟹具有很高的抗药性。这项研究突出了赋予蚊媒对化学杀虫剂多重耐药性的复杂机制网络，对设计和实施媒介抗性管理策略具有重要意义。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号