Benznidazole Biotransformation and Multiple Targets in Trypanosoma cruzi Revealed by Metabolomics

Andrea Trochine; Darren J. Creek; Paula Faral-Tello; Michael P. Barrett; Carlos Robello

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Benznidazole Biotransformation and Multiple Targets in Trypanosoma cruzi Revealed by Metabolomics

机译：代谢组学揭示苯并尼唑在克氏锥虫中的生物转化和多个靶标

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Background The first line treatment for Chagas disease, a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi, involves administration of benznidazole (Bzn). Bzn is a 2-nitroimidazole pro-drug which requires nitroreduction to become active, although its mode of action is not fully understood. In the present work we used a non-targeted MS-based metabolomics approach to study the metabolic response of T. cruzi to Bzn.

机译：背景技术恰加斯氏病的一线治疗是一种由原生动物寄生虫克氏锥虫引起的被忽视的热带病，涉及苯甲硝唑（Bzn）的给药。 Bzn是一种2-硝基咪唑前药，尽管尚未完全了解其作用方式，但它需要硝化才能变得活跃。在目前的工作中，我们使用了非靶向的基于MS的代谢组学方法来研究克鲁氏锥虫对Bzn的代谢反应。

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《PLOS Neglected Tropical Diseases》 |2014年第5期|共15页
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Andrea Trochine; Darren J. Creek; Paula Faral-Tello; Michael P. Barrett; Carlos Robello;
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1. Notch receptor expression in Trypanosoma cruzi Trypanosoma cruzi ‐infected human umbilical vein endothelial cells treated with benznidazole or simvastatin revealed by microarray analysis [J] . Campos‐Estrada Carolina, González‐Herrera Fabiola, Greif Gonzalo, Cell biology international. . 2020,第5期

机译：在胰蛋白酶瘤Cruzi TrypanoSoma Cruzi-infacted人脐静脉内皮细胞的缺口受体表达，用苯并咪唑或辛伐他汀揭示的微阵列分析
2. Transcriptome and Functional Genomics Reveal the Participation of Adenine Phosphoribosyltransferase in Trypanosoma cruzi Trypanosoma cruzi Resistance to Benznidazole [J] . García‐Huertas Paola, Mejía‐Jaramillo Ana María, González Laura, Journal of cellular biochemistry. . 2017,第7期

机译：转录组和功能基因组学揭示了腺嘌呤磷酰基转移酶参与促蛋白酶瘤Cruzi Trypanosoma Cruzi抗苯并咪唑的抗性
3. Pentamidine antagonizes the benznidazole's effect in vitro, and lacks of synergy in vivo: Implications about the polyamine transport as an anti-Trypanosoma cruzi target [J] . Experimental parasitology . 2016,第Null期

机译：喷他idine在体外拮抗苯硝唑的作用，而在体内缺乏协同作用：多胺转运作为抗克氏锥虫靶点的意义
4. Triple SILAC Phosphoproteomics Metabolomics Reveals Drug Targets in Multiple Myeloma Cells: a Case for CID over HCD using the Orbitrap Elite [C] . Susanne B. Breitkopf, Min Yuan, John M. Asara American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2013

机译：三重氧化磷蛋白酶和代谢组学揭示了多发性骨髓瘤细胞中的药物靶标：使用壁图精英对HCD进行CID的情况
5. Design, synthesis, and biological evaluation of molecules of medicinal interest: Inhibitors of mammalian and Trypanosoma cruzi protein farnesyltransferase and Trypanosoma cruzi lanosterol-14-alpha-demethylase. [D] . Lockman, Jeffrey William. 2003

机译：设计，合成和具有药用价值的分子的生物学评估：哺乳动物和克鲁斯锥虫蛋白法尼基转移酶和克鲁斯锥虫羊毛甾醇14-α-脱甲基酶的抑制剂。
6. Benznidazole Biotransformation and Multiple Targets in Trypanosoma cruzi Revealed by Metabolomics [O] . Andrea Trochine, Darren J. Creek, Paula Faral-Tello, 2014

机译：代谢组学揭示苯并尼唑在克氏锥虫中的生物转化和多个靶标
7. Benznidazole Biotransformation and Multiple Targets in Trypanosoma cruzi Revealed by Metabolomics [O] . Trochine, Andrea, Creek, Darren J., Faral Tello, Paula, 2017

机译：代谢组学揭示苯并尼唑在克氏锥虫中的生物转化和多个靶标

Benznidazole Biotransformation and Multiple Targets in Trypanosoma cruzi Revealed by Metabolomics

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