...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>PLoS One >Safety Concern between Autologous Fat Graft, Mesenchymal Stem Cell and Osteosarcoma Recurrence
【24h】

Safety Concern between Autologous Fat Graft, Mesenchymal Stem Cell and Osteosarcoma Recurrence

机译：自体脂肪移植，间充质干细胞与骨肉瘤复发之间的安全性关注

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background Osteosarcoma is the most common malignant primary bone tumour in young adult treated by neo adjuvant chemotherapy, surgical tumor removal and adjuvant multidrug chemotherapy. For correction of soft tissue defect consecutive to surgery and/or tumor treatment, autologous fat graft has been proposed in plastic and reconstructive surgery. Principal Findings We report here a case of a late local recurrence of osteosarcoma which occurred 13 years after the initial pathology and 18 months after a lipofilling procedure. Because such recurrence was highly unexpected, we investigated the possible relationship of tumor growth with fat injections and with mesenchymal stem/stromal cell like cells which are largely found in fatty tissue. Results obtained in osteosarcoma pre-clinical models show that fat grafts or progenitor cells promoted tumor growth. Significance These observations and results raise the question of whether autologous fat grafting is a safe reconstructive procedure in a known post neoplasic context.
机译：背景骨肉瘤是年轻成人中最常见的恶性原发性骨肿瘤，通过新辅助化疗，手术切除肿瘤和辅助多药化疗进行治疗。为了在手术和/或肿瘤治疗之后矫正软组织缺损，已经在整形和重建手术中提出了自体脂肪移植。主要发现我们在这里报告一例晚期骨肉瘤局部复发的病例，该病例在最初的病理学发生后13年，在加脂手术后发生18个月。由于这种复发非常出乎意料，因此我们研究了肿瘤生长与注射脂肪以及与在脂肪组织中大量发现的间充质干/基质细胞样细胞的关系。在骨肉瘤临床前模型中获得的结果表明，脂肪移植物或祖细胞可促进肿瘤生长。意义这些观察和结果提出了一个问题，即自体脂肪移植在已知的肿瘤后环境中是否是安全的重建方法。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号