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首页> 外文期刊>PLoS One >Rearrangement of Retinogeniculate Projection Patterns after Eye-Specific Segregation in Mice
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Rearrangement of Retinogeniculate Projection Patterns after Eye-Specific Segregation in Mice

机译：特定于眼球的小鼠分离后视网膜生成投影模式的重排

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It has been of interest whether and when the rearrangement of neuronal circuits can be induced after projection patterns are formed during development. Earlier studies using cats reported that the rearrangement of retinogeniculate projections could be induced even after eye-specific segregation has occurred, but detailed and quantitative characterization of this rearrangement has been lacking. Here we delineate the structural changes of retinogeniculate projections in the C57BL/6 mouse in response to monocular enucleation (ME) after eye-specific segregation. When ME was performed after eye-specific segregation, rearrangement of retinogeniculate axons in the dorsal lateral geniculate nucleus (dLGN) was observed within 5 days. Although this rearrangement was observed both along the dorsomedial-ventrolateral and outer-inner axes in the dLGN, it occurred more rapidly along the outer-inner axis. We also examined the critical period for this rearrangement and found that the rearrangement became almost absent by the beginning of the critical period for ocular dominance plasticity in the primary visual cortex. Taken together, our findings serve as a framework for the assessment of phenotypes of genetically altered mouse strains as well as provide insights into the mechanisms underlying the rearrangement of retinogeniculate projections.
机译：有趣的是，在显影过程中形成投影图案后，是否以及何时可以诱发神经回路的重排。较早的使用猫的研究报告说，即使在发生眼部特定的分离后，也可能诱发视网膜生成物投射的重排，但是缺乏这种重排的详细和定量表征。在这里，我们描述了在C57BL / 6小鼠中，针对眼特定的分离后，对单眼摘除（ME）的视网膜生成突起的结构变化。当在眼特异性分离后进行ME时，在5天内观察到了背外侧膝状核（dLGN）中的视网膜原轴突的重排。尽管在dLGN的背侧-腹侧和内外轴均观察到这种重排，但沿外内轴更迅速地发生。我们还检查了这种重排的关键时期，发现在主要视觉皮层的眼优势可塑性的关键时期开始之前，几乎没有重排。综上所述，我们的发现可作为评估基因改变的小鼠品系表型的框架，并提供对成视网膜的投射重排的潜在机制的见解。

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