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首页> 外文期刊>Polish Archives of Internal Medicine >Activity of antioxidative enzymes and concentration of malondialdehyde as oxidative status markers in women with newly diagnosed Graves?Basedow disease and after thiamazole therapy leading to euthyroidism
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Activity of antioxidative enzymes and concentration of malondialdehyde as oxidative status markers in women with newly diagnosed Graves?Basedow disease and after thiamazole therapy leading to euthyroidism

机译：新诊断为Graves？Basedow病的妇女以及噻唑治疗后导致甲状腺功能亢进的妇女的抗氧化酶活性和丙二醛浓度作为氧化状态标志物

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Introduction. Hyperthyroidism in the course of Graves?Basedow disease leads to intensification of oxidative processes and increased production of free oxygen radicals. It results in abnormal oxidative status of the organism. Objectives. Aim of this work was to assess the dynamics of oxidative status changes in women with Graves?Basedow disease before and after treatment with thiamazole. Patients and methods. Studies were carried out in 20 women with newly diagnosed hyperthyroidism in the course of Graves?Basedow disease and in 15 healthy women. Measurements of activity of antioxidant enzymes – superoxide dismutase (cytosolic copper/zinc isoform – Cu/ZnSOD, mitochondrial manganese isoform – MnSOD and extracellular copper/zinc isoform – EC?SOD) and glutathione peroxidase (GPx), as well as of malondialdehyde (MDA) concentration were performed twice, i.e. before the treatment and after 3–7 months of thiamazole therapy (euthyroidism). Results. Before the treatment, higher MnSOD plasma activity and lower EC?SOD activity were observed in women with hyperthyroidism in comparison with the control group, whereas the erythrocyte Cu/ZnSOD activity did not differ between the groups. Besides, women with hyperthyroidism had higher GPx activity in red blood cells. In this group studies have demonstrated higher plasma MDA levels, without any differences between the groups in MDA levels in red blood cells. After thiamazole therapy no differences could be demonstrated in MnSOD, EC?SOD, Cu/ZnSOD and GPx activities and MDA level between the groups. Conclusions. Women with hyperthyroidism in the course of Graves?Basedow disease experience abnormal oxidative status of the organism, and induction of euthyroidism after therapy with thiamazole results in resolution of these abnormalities.
机译：介绍。 Graves-Basedow病程中的甲状腺功能亢进症会导致氧化过程加剧并增加游离氧自由基的产生。这会导致生物体的氧化状态异常。目标。这项工作的目的是评估噻唑治疗前后Graves-Basedow病女性的氧化状态变化动态。患者和方法。在Graves？Basedow病程中，对20名新诊断出甲亢的妇女和15名健康妇女进行了研究。测量抗氧化酶的活性–超氧化物歧化酶（胞质铜/锌同工酶– Cu / ZnSOD，线粒体锰同工酶– MnSOD和细胞外铜/锌同工酶– EC？SOD）和谷胱甘肽过氧化物酶（GPx）以及丙二醛（MDA） ）进行两次浓缩，即在治疗之前和噻唑治疗3-7个月后（甲状腺功能亢进）。结果。治疗前，甲状腺功能亢进症妇女与对照组相比，有较高的MnSOD血浆活性和较低的ECαSOD活性，而两组间的红细胞Cu / ZnSOD活性无差异。此外，甲状腺功能亢进症妇女的红细胞中GPx活性较高。在该组中的研究表明，血浆MDA水平较高，各组之间红细胞中MDA水平没有任何差异。噻唑治疗后，两组之间的MnSOD，EC？SOD，Cu / ZnSOD和GPx活性以及MDA水平均无差异。结论。在Graves-Basedow病程中患有甲状腺功能亢进症的女性会经历机体的氧化状态异常，而用噻唑治疗后诱发甲状腺功能亢进可解决这些异常现象。

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