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首页> 外文期刊>European thyroid journal >Arterial Stiffness and Blood Pressure in Patients Newly Diagnosed with Graves' Disease Compared with Euthyroid Controls
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Arterial Stiffness and Blood Pressure in Patients Newly Diagnosed with Graves' Disease Compared with Euthyroid Controls

机译：与Euthyroid对照相比，动脉僵硬和血压患者患者患有Graves疾病

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Introduction and Objective: The excess cardiovascular morbidity and mortality in hyperthyroidism and Graves' disease (GD) is inadequately understood. We aimed to elucidate whether well-established cardiovascular risk factors such as arterial stiffness in terms of pulse wave velocity (PWV) and blood pressure differ in GD and controls. Methods: This was a cross-sectional study comparing 55 hyperthyroid patients with newly diagnosed GD and 55 euthyroid, population-based controls matched for age, sex and menopausal status. PWV and blood pressure were measured in office (SphygmoCor Xcel) and 24-h ambulatory settings (Arteriograph). Differences between groups were assessed using adjusted linear regression analysis. Results: Compared to controls, GD patients showed higher PWV in the 24-h but not in the office setting with an adjusted 24-h PWV difference of 1.0 (95% CI: 0.6-1.5) m/s. PWV was higher in GD at both day and night, and nightly PWV dipping was lower (-5.5, 95% CI: -10.4 to -0.6%). Furthermore, central and brachial pulse pressure was significantly higher in both the office and 24-h setting, whereas nightly central pulse pressure dipping was significantly lower in GD (-5.4, 95% CI: -10.5 to -0.2%). Mean arterial pressure did not differ between the groups. Conclusions: Despite comparable blood pressure, GD is associated with a higher 24-h PWV that was not detected in the office setting. Pulse pressure was higher in GD, whereas mean arterial pressure did not differ between the groups. Longitudinal studies should pursue whether higher PWV might be a piece to the puzzle of understanding the increased risk of cardiovascular disease in hyperthyroidism and GD.
机译：介绍与目标：甲状腺功能亢进和坟墓疾病（GD）的过度心血管发病和死亡率不足以理解。我们的旨在阐明脉搏波速度（PWV）和血压方面是否熟悉的心血管危险因素如动脉刚度，并且在GD和对照中不同。方法：这是一项横截面研究，比较55例甲状腺功能亢进患者新诊断的GD和55例Euthyroid，群体的群体对抗符合年龄，性别和更年期状态。在办公室（SpygMocor Xcel）和24-H外动脉设置（动脉仪）中测量PWV和血压。使用调整的线性回归分析评估组之间的差异。结果：与对照相比，GD患者在24-H中显示出更高的PWV，但在办公室环境中不具有1.0（95％CI：0.6-1.5）M / s的24-H PWV差异。在白天和夜间的GD中PWV较高，夜间PWV浸渍较低（-5.5,95％CI：-10.4至-0.6％）。此外，办公室和24小时设定中，中央和臂脉冲压力显着高，而夜间中央脉冲压力浸渍在GD中显着降低（-5.4,95％CI：-10.5至-0.2％）。平均动脉压在组之间没有差异。结论：尽管血压可比，GD与在办公室环境中未检测到的24小时PWV相关。 GD脉冲压力较高，而平均动脉压在组之间没有差异。纵向研究应该追求更高的PWV是否可能是了解甲状腺功能亢进症和GD的心血管疾病风险增加的拼图。

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