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首页> 外文期刊>Primary care companion to the journal of clinical psychiatry >Adherence to Selective Serotonin and Serotonin-Norepinephrine Reuptake Inhibitor Prescriptions Affects Overall Medication Adherence in Older Persons: Evidence From the Italian Nationwide OsMed Health-DB Database
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Adherence to Selective Serotonin and Serotonin-Norepinephrine Reuptake Inhibitor Prescriptions Affects Overall Medication Adherence in Older Persons: Evidence From the Italian Nationwide OsMed Health-DB Database

机译：选择性5-羟色胺和5-羟色胺-去甲肾上腺素再摄取抑制剂处方的依从性影响老年人的总体药物依从性：来自意大利全国OsMed Health-DB数据库的证据

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Objective: This study aimed to evaluate prevalence of prescription of and adherence to selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) and whether adherence to these classes of drugs affects overall medication adherence in older persons. Methods: In a cross-sectional analysis of administrative data comprehensive of all prescribed drugs reimbursed by the Italian national health care system, new prescriptions of SSRIs and SNRIs to persons aged 65 years or older were analyzed (n = 380,400 in 2011; 395,806 in 2012; 409,741 in 2013, from a total sample of 3,762,299 persons aged 65 years or older) as well as prescriptions of antihypertensives, statins, other psychiatric drugs, antidiabetics, antiplatelets, anticoagulants, drugs for chronic obstructive pulmonary disease, and antiosteoporotics. Adherence was estimated by calculating the proportion of days covered by drugs dispensed during a period of 365 days. Adherence was defined as a proportion of days covered of more than 80%. Results: Prevalence of SSRI and SNRI prescriptions varied from 11.4% in 2011 to 12.1% in 2013. Adherence to SSRI and SNRI prescriptions ranged from 31.2% in persons aged ≥ 95 years in 2011 to 41.8% in persons aged 75–84 years in 2013. Persons adherent to SSRI and SNRI prescriptions were more likely to be adherent to the other medications, after adjustment for age, gender, and number of drugs prescribed. The highest association was found for adherence to psychiatric drugs (OR = 1.9; 95% CI, 1.8–2.0). Conclusions: Adherence to SSRI and SNRI prescriptions is poor in older persons. However, people adherent to these classes of antidepressants are more likely to be adherent to the other medications they are prescribed. Studies are needed to evaluate the reasons for and the potential benefits of increasing adherence to antidepressants on overall adherence.
机译：目的：本研究旨在评估选择性5-羟色胺再摄取抑制剂（SSRIs）和5-羟色胺-去甲肾上腺素再摄取抑制剂（SNRIs）的处方和依从性，以及对此类药物的依从性是否会影响老年人的总体药物依从性。方法：在对意大利国家医疗体系报销的所有处方药的行政数据进行综合的横断面分析中，分析了65岁以上老年人的SSRI和SNRI的新处方（2011年为380,400; 2012年为395,806） ; 2013年为409,741例患者，样本总数为3,762,299例65岁或65岁以上的老年人），以及抗高血压药，他汀类药物，其他精神药物，抗糖尿病药，抗血小板药，抗凝药，用于慢性阻塞性肺疾病的药物和抗骨质疏松药的处方。依从性是通过计算365天内分配的药物所占天数的比例来估算的。坚持被定义为覆盖天数超过80％的比例。结果：SSRI和SNRI处方的患病率从2011年的11.4％到2013年的12.1％。对SSRI和SNRI处方的依从性从2011年的31.2％（≥95岁的人）到41.8％（2013年的75-84岁）不等在调整了年龄，性别和处方药数量之后，遵守SSRI和SNRI处方的人更有可能遵守其他药物。发现对精神药物的依从性最高（OR = 1.9; 95％CI，1.8–2.0）。结论：老年人对SSRI和SNRI处方的依从性差。但是，坚持使用这些抗抑郁药的人更有可能坚持使用其他处方药。需要进行研究以评估增加抗抑郁药依从性对整体依从性的原因和潜在益处。

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