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MOLECULAR MECHANISM OF SELECTIVE SEROTONIN REUPTAKE INHIBITORS (SSRI'S) INTERACTIONS WITH SEROTONIN TRANSPORTER

机译：选择性血清素再摄取抑制剂（SSRI）与血清素转运蛋白相互作用的分子机制

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Serotonin selective reuptake inhibitors (SSRIs) are currently among the most frequently prescribed therapeutic agents in depression. Their therapeutic use also includes obsessive-compulsive disorder, panic disorder and bulimia. The serotonin transporter (SERT), which consists of 12 transmembrane helices (TMH) with the amino and carboxy terminals localized intracellularly, is the molecular target of SSRIs. The understanding of the mechanism of action of SERT remains a primary goal in the search for developing novel treatments for diseases associated with serotonergic dysfunction.

机译：血清素选择性再摄取抑制剂（SSRIS）目前是抑郁症中最常规定的治疗剂中的最常规定的治疗剂。他们的治疗用途还包括强迫症，恐慌症和贪食症。血清素转运蛋白（SERT），由12个跨膜螺旋（TMH）组成，其中氨基和羧基末端局部化细胞内，是SSRIS的分子靶标。对SERT行动机制的理解仍然是寻求开发与血清onOronergic功能障碍相关的疾病的新疗法的主要目标。

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《the European Peptide Symposium》|2007年||共2页
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Malgorzata Jaronczyk; Zdzislaw Chilmonczyk; Aleksander P. Mazurek;
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1. Human Therapeutic Plasma Levels of the Selective Serotonin Reuptake Inhibitor (SSRI) Sertraline Decrease Serotonin Reuptake Transporter Binding and Shelter-Seeking Behavior in Adult Male Fathead Minnows [J] . Theodore W. Valenti Jr, Georgianna G. Gould, Jason P. Berninger, Environmental Science & Technology . 2012,第4期

机译：选择性5-羟色胺再摄取抑制剂（SSRI）舍曲林的人体治疗血浆水平降低成年雄性黑头黑猩猩中5-羟色胺再摄取转运蛋白的结合和庇护行为
2. Allelic variation in the serotonin transporter promoter affects neuromodulatory effects of a selective serotonin transporter reuptake inhibitor (SSRI). [J] . Eichhammer P, Langguth B, Wiegand R, Psychopharmacology . 2003,第3期

机译：5-羟色胺转运蛋白启动子中的等位基因变化影响选择性5-羟色胺转运蛋白再摄取抑制剂（SSRI）的神经调节作用。
3. Allelic variation in the serotonin transporter promoter affects neuromodulatory effects of a selective serotonin transporter reuptake inhibitor (SSRI) [J] . Peter Eichhammer, Berthold Langguth, Rainer Wiegand, Psychopharmacology . 2003,第3期

机译：5-羟色胺转运蛋白启动子的等位基因变化影响选择性5-羟色胺转运蛋白再摄取抑制剂（SSRI）的神经调节作用。
4. MOLECULAR MECHANISM OF SELECTIVE SEROTONIN REUPTAKE INHIBITORS (SSRI'S) INTERACTIONS WITH SEROTONIN TRANSPORTER [C] . Malgorzata Jaronczyk, Zdzislaw Chilmonczyk, Aleksander P. Mazurek the European Peptide Symposium . 2007

机译：选择性血清素再摄取抑制剂（SSRI）与血清素转运蛋白相互作用的分子机制
5. Synthesis and SAR study of meperidine analogues as selective serotonin reuptake inhibitors (SSRIs). [D] . Gu, Xiaobo. 2010

机译：作为选择性5-羟色胺再摄取抑制剂（SSRIs）的哌替啶类似物的合成和SAR研究。
6. Human Therapeutic Plasma Levels of the Selective Serotonin Reuptake Inhibitor (SSRI) Sertraline Decrease Serotonin Reuptake Transporter Binding and Shelter-Seeking Behavior in Adult Male Fathead Minnows [O] . Theodore W. Valenti Jr., Georgianna G. Gould, Jason P. Berninger, -1

机译：人类血浆治疗的选择性5-羟色胺再摄取抑制剂的水平（ssRI）舍曲林降低血清素再摄取转运绑定和成年雄性黑头呆鱼庇护寻求行为
7. The association of serotonin transporter genotypes and selective serotonin reuptake inhibitor (SSRI)-associated sexual side effects: possible relationship to oral contraceptives [O] . Bishop, Jeffrey R., Ellingrod, Vicki L., Akroush, Michael, 2009

机译：血清素转运蛋白基因型与选择性5-羟色胺再摄取抑制剂（ssRI）相关的性副作用的关联：与口服避孕药的可能关系

MOLECULAR MECHANISM OF SELECTIVE SEROTONIN REUPTAKE INHIBITORS (SSRI'S) INTERACTIONS WITH SEROTONIN TRANSPORTER

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