Allelic variation in the serotonin transporter promoter affects neuromodulatory effects of a selective serotonin transporter reuptake inhibitor (SSRI)

Peter Eichhammer; Berthold Langguth; Rainer Wiegand; Alexander Kharraz; Ulrich Frick; Göran Hajak

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Allelic variation in the serotonin transporter promoter affects neuromodulatory effects of a selective serotonin transporter reuptake inhibitor (SSRI)

机译：5-羟色胺转运蛋白启动子的等位基因变化影响选择性5-羟色胺转运蛋白再摄取抑制剂（SSRI）的神经调节作用。

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Antidepressant efficacy of selective serotonin reuptake inhibitors (SSRIs) has been shown to depend on functional polymorphisms within the promoter region of the serotonin transporter gene (5-HTTLPR). This gene gives rise to a biallelic polymorphism designated long (l) and short (s). Homozygosity for the long variant (ll-genotype) is associated with a two times more efficient 5-HT uptake compared to the s/l- or s/s-genotype. Paired pulse transcranial magnetic stimulation is a feasible tool in detecting changes of motor cortex excitability induced by SSRIs.

机译：选择性5-羟色胺再摄取抑制剂（SSRIs）的抗抑郁功效已显示取决于5-羟色胺转运蛋白基因（5-HTTLPR）启动子区域内的功能多态性。该基因引起双等位基因多态性，称为长（l）和短（s）。与s / l-或s / s-基因型相比，长变异（II基因型）的纯合性与5-HT吸收效率高两倍有关。配对脉冲经颅磁刺激是检测SSRIs引起的运动皮层兴奋性变化的可行工具。

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来源
《Psychopharmacology》 |2003年第3期|294-297|共4页
作者
Peter Eichhammer; Berthold Langguth; Rainer Wiegand; Alexander Kharraz; Ulrich Frick; Göran Hajak;
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作者单位

Department of Psychiatry and Psychotherapy University of Regensburg;

Department of Psychiatry and Psychotherapy University of Regensburg;

Department of Psychiatry and Psychotherapy University of Regensburg;

Department of Psychiatry and Psychotherapy University of Regensburg;

Department of Psychiatry and Psychotherapy University of Regensburg;

Department of Psychiatry and Psychotherapy University of Regensburg;

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正文语种 eng
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关键词
Paired pulse transcranial magnetic stimulation; Serotonin gene transporter polymorphism; Serotonin transporter reuptake inhibitor; Motor cortex excitability;

机译：配对脉冲经颅磁刺激;5-羟色胺基因转运蛋白多态性;5-羟色胺转运蛋白再摄取抑制剂;运动皮层兴奋性;

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1. Allelic variation in the serotonin transporter promoter affects neuromodulatory effects of a selective serotonin transporter reuptake inhibitor (SSRI). [J] . Eichhammer P, Langguth B, Wiegand R, Psychopharmacology . 2003,第3期

机译：5-羟色胺转运蛋白启动子中的等位基因变化影响选择性5-羟色胺转运蛋白再摄取抑制剂（SSRI）的神经调节作用。
2. The association of serotonin transporter genotypes and selective serotonin reuptake inhibitor (SSRI)-associated sexual side effects: possible relationship to oral contraceptives. [J] . Bishop JR, Ellingrod VL, Akroush M, Human psychopharmacology: clinical and experimental . 2009,第3期

机译：血清素转运蛋白基因型与选择性血清素再摄取抑制剂（SSRI）相关的性副作用的关联：可能与口服避孕药有关。
3. Human Therapeutic Plasma Levels of the Selective Serotonin Reuptake Inhibitor (SSRI) Sertraline Decrease Serotonin Reuptake Transporter Binding and Shelter-Seeking Behavior in Adult Male Fathead Minnows [J] . Theodore W. Valenti Jr, Georgianna G. Gould, Jason P. Berninger, Environmental Science & Technology . 2012,第4期

机译：选择性5-羟色胺再摄取抑制剂（SSRI）舍曲林的人体治疗血浆水平降低成年雄性黑头黑猩猩中5-羟色胺再摄取转运蛋白的结合和庇护行为
4. MOLECULAR MECHANISM OF SELECTIVE SEROTONIN REUPTAKE INHIBITORS (SSRI'S) INTERACTIONS WITH SEROTONIN TRANSPORTER [C] . Malgorzata Jaronczyk, Zdzislaw Chilmonczyk, Aleksander P. Mazurek the European Peptide Symposium . 2007

机译：选择性血清素再摄取抑制剂（SSRI）与血清素转运蛋白相互作用的分子机制
5. Synthesis and SAR study of meperidine analogues as selective serotonin reuptake inhibitors (SSRIs). [D] . Gu, Xiaobo. 2010

机译：作为选择性5-羟色胺再摄取抑制剂（SSRIs）的哌替啶类似物的合成和SAR研究。
6. The Association of Serotonin Transporter Genotypes and Selective Serotonin Reuptake Inhibitor (SSRI) Associated Sexual Side Effects: Possible Relationship to Oral Contraceptives [O] . Jeffrey R. Bishop, Vicki L. Ellingrod, Michael Akroush, -1

机译：血清素转运蛋白基因型和选择性血清素再摄取抑制剂（SSRI）相关性副作用的关联：对口语避孕药的可能关系
7. The association of serotonin transporter genotypes and selective serotonin reuptake inhibitor (SSRI)-associated sexual side effects: possible relationship to oral contraceptives [O] . Bishop, Jeffrey R., Ellingrod, Vicki L., Akroush, Michael, 2009

机译：血清素转运蛋白基因型与选择性5-羟色胺再摄取抑制剂（ssRI）相关的性副作用的关联：与口服避孕药的可能关系

Allelic variation in the serotonin transporter promoter affects neuromodulatory effects of a selective serotonin transporter reuptake inhibitor (SSRI)

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