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首页> 外文期刊>Primary care companion to the journal of clinical psychiatry >Assessing the Reliability and Validity of the Sheehan Irritability Scale in Patients With Major Depressive Disorder
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Assessing the Reliability and Validity of the Sheehan Irritability Scale in Patients With Major Depressive Disorder

机译：评估严重抑郁症患者的希恩易怒量表的信度和效度

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Objective: Irritability is a significant component in the clinical manifestation of major depressive disorder (MDD). The Sheehan Irritability Scale (SIS) was developed to assess irritability-related symptoms in patients with psychiatric disorders. Data from a phase 2 clinical trial (June 2008–July 2009) was utilized to evaluate the psychometric properties of the SIS. The trial population included patients diagnosed with MDD, according to DSM-IV and confirmed via the MINI diagnostic scale, who had inadequate response to citalopram. Method: The secondary analyses included 586 patients from the United States and India. Data from the SIS, depression severity measures (17-item Hamilton Depression Rating Scale [HDRS-17], Montgomery-Asberg Depression Rating Scale [MADRS], Quick Inventory of Depressive Symptomatology–Self-Report [QIDS-SR]), and other measures (Sheehan Disability Scale [SDS], Clinical Global Impressions-Severity of Illness scale [CGI-S]) were used in the psychometric evaluation. All statistical tests used a significance level of .05 unless otherwise noted. Results: Internal consistency (0.92–0.99) and test-retest reliability (0.83 to 0.98) were excellent. Concurrent validity was demonstrated through strong correlations between the SIS total score and HDRS-17, QIDS-SR, SDS, CGI-S, and MADRS scores. SIS total scores were significantly different by clinical severity level (P .001). Minimally important difference estimates suggest that a 7- to 8-point change in the SIS total score may be clinically meaningful. Conclusions: The SIS has excellent reliability, acceptable validity, and good responsiveness, making the SIS appropriate for use in clinical research and practice. Trial Registration: ClinicalTrials.gov identifier: NCT00692445
机译：目的：易激惹性是重度抑郁症（MDD）临床表现的重要组成部分。开发了Sheehan易怒量表（SIS），以评估精神疾病患者的与易怒性相关的症状。来自2期临床试验（2008年6月至2009年7月）的数据用于评估SIS的心理测量特性。根据DSM-IV，试验人群包括诊断为MDD并通过MINI诊断量表确认的对西酞普兰反应不足的患者。方法：次要分析包括来自美国和印度的586例患者。来自SIS的数据，抑郁症严重程度指标（汉密尔顿抑郁症评定量表[HDRS-17]，蒙哥马利-阿斯伯格抑郁症评定量表[MADRS]，抑郁症症状快速清单-自我报告[QIDS-SR]）以及其他数据心理测量使用了测量指标（Sheehan残疾量表[SDS]，临床总体印象-疾病严重程度量表[CGI-S]）。除非另有说明，否则所有统计检验的显着性水平均为0.05。结果：内部一致性（0.92-0.99）和重测信度（0.83至0.98）极好。 SIS总评分与HDRS-17，QIDS-SR，SDS，CGI-S和MADRS评分之间具有很强的相关性，从而证明了并发有效性。 SIS总分在临床严重程度上有显着差异（P <.001）。最低限度的重要差异估计表明SIS总分的7到8点变化可能具有临床意义。结论：SIS具有极好的可靠性，可接受的有效性和良好的响应能力，使SIS适合在临床研究和实践中使用。试验注册：ClinicalTrials.gov标识符：NCT00692445

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