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首页> 外文期刊>Proceedings of Singapore Healthcare >The polymorphisms in angiotensin-converting enzyme and angiotensin-converting enzyme 2 are not associated with thoracic aortic diseases and coronary heart disease:
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The polymorphisms in angiotensin-converting enzyme and angiotensin-converting enzyme 2 are not associated with thoracic aortic diseases and coronary heart disease:

机译：血管紧张素转化酶和血管紧张素转化酶2的多态性与胸主动脉疾病和冠心病无关：

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Introduction:The polymorphisms of the angiotensin-converting enzyme (ACE) and angiotensin-converting enzyme 2 (ACE2) genes have been demonstrated to be involved in some cardiovascular diseases. We hypothesised that the polymorphisms of ACE and ACE2 relate to the formation of thoracic aortic diseases and coronary heart disease.Methods:A total of 86 patients (four groups: thoracic aortic dissection; thoracic aortic aneurysm; coronary heart disease; and control group) were recruited. The ACE I/D polymorphism and the ACE2 (A8790G) polymorphism were measured in all patient samples.Results:There were no significant differences in groups with regard to either the ACE I/D polymorphism or the ACE2 (A8790G) polymorphism.Conclusion:The polymorphisms of the ACE and ACE2 genes are not associated with thoracic aortic dissection, thoracic aortic aneurysm and coronary heart disease.
机译：简介：血管紧张素转换酶（ACE）和血管紧张素转换酶2（ACE2）基因的多态性已被证明与某些心血管疾病有关。我们假设ACE和ACE2的多态性与胸主动脉疾病和冠心病的形成有关。方法：共86例患者（四组：胸主动脉夹层;胸主动脉瘤;冠心病;对照组）。被招募。在所有患者样本中均测量了ACE I / D多态性和ACE2（A8790G）多态性。结果：ACE I / D多态性或ACE2（A8790G）多态性在各组中均无显着差异。 ACE和ACE2基因的多态性与胸主动脉夹层，胸主动脉瘤和冠心病无关。

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