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首页> 外文期刊>Proceedings of the Japan Academy, Series B. Physical and Biological Sciences >Gastric cancer screening by combined assay for serum anti-Helicobacter pylori IgG antibody and serum pepsinogen levels — “ABC method”
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Gastric cancer screening by combined assay for serum anti-Helicobacter pylori IgG antibody and serum pepsinogen levels — “ABC method”

机译：通过血清抗幽门螺杆菌IgG抗体和胃蛋白酶原水平的联合检测筛查胃癌—“ ABC方法”

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摘要

The current status of screening for gastric cancer-risk (gastritis A, B, C, D) method using combined assay for serum anti-Helicobacter pylori (Hp) IgG antibody and serum pepsinogen (PG) levels, “ABC method”, was reviewed and the latest results of our ongoing trial are reported. It was performed using the following strategy: Subjects were classified into 1 of 4 risk groups based on the results of the two serologic tests, anti-Hp IgG antibody titers and the PG I and II levels: Group A [Hp(−)PG(−)], infection-free subjects; Group B [Hp(+)PG(−)], chronic atrophic gastritis (CAG) free or mild; Group C [Hp(+)PG(+)], CAG; Group D [Hp(−)PG(+)]), severe CAG with extensive intestinal metaplasia. Continuous endoscopic follow-up examinations are required to detect early stages of gastric cancer. Asymptomatic Group A, which accounts for 50–80% of all the subjects may be excluded from the secondary endoscopic examination, from the viewpoint of efficiency. Hp-infected subjects should be administered eradication treatment aimed at the prevention of gastric cancer.

(Communicated by Takashi SUGIMURA, M.J.A.)
机译：血清抗幽门螺杆菌（IgG）IgG抗体和血清联合检测法筛查胃癌风险（A，B，C，D型胃癌）方法的现状审查了血清胃蛋白酶原（PG）水平，“ ABC方法”，并报告了我们正在进行的试验的最新结果。它是通过以下策略进行的：根据两种血清学测试，抗Hp IgG抗体滴度和PG I和II水平的结果，将受试者分为4个风险组之一。 [ Hp （-）PG（-）]，无感染者; B组[ Hp （+）PG（-）]，无或轻度的慢性萎缩性胃炎（CAG）; C组[ Hp （+）PG（+）]，CAG; D组[ Hp （-）PG（+）]），严重的CAG，具有广泛的肠上皮化生。需要连续的内窥镜随访检查以发现早期胃癌。从效率的角度来看，无症状的A组占所有受试者的50-80％，可以从二次内镜检查中排除。 Hp 感染的受试者应进行根除治疗，以预防胃癌。

（由Takashi SUGIMURA，M.J.A。交流）

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