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Gastric Cancer Screening by Combined Assay for Serum Anti-Helicobacter pylori IgG Antibody and Serum Pepsinogen Levels - The ABC Method

机译：血清抗幽门螺杆菌IgG抗体和血清胃蛋白酶原水平联合测定的胃癌筛查-ABC方法

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Background: Helicobacter pylori (Hp) infection and gastric atrophy are both risk factors for gastric cancer. Recently it has been found that X-ray examination for gastric cancer screening does not have much effect on the detection rate for gastric cancer in Japan. A candidate for a new mass screening for gastric cancer, the ABC method, using the combination assay of Hp and serum pepsinogen, was useful for identifying the development of gastric cancer in high-risk and low risk populations. People with higher cancer risk are recommended to receive endoscopy. The ABC method was carried out as a gastric cancer mass-screening on the initiative of Nishitokyo Medical Association in Nishitokyo city from 2011. This paper reviewed the present status of gastric cancer screening using the ABC method, including the latest results of our ongoing screening. Summary: We report results for 36,627 individuals from 2011 to 2013. Among them, 16,965 received blood examination for the ABC method. Of those, 8,083 planned to undergo endoscopic examination according to stratification of the risk for the development of gastric cancer. In fact, a total of 2,911 individuals underwent endoscopic examination. Gastric cancer was detected in 65 patients, including 52 (80%) diagnosed with early gastric cancer. The ABC method was not organized screening but opportunistic screening. X-ray examination was the organized screening that was ongoing during the same period. Detection cost for 1 gastric cancer case using the ABC method was cheaper than the conventional X-ray screening method ((sic)1,267,452 vs. (sic)2,807,763). Key Messages: Although further large epidemiological studies are required, the ABC method might be positioned as an effective mass screening for gastric cancer. (C) 20165. Karger AG, Basel
机译：背景：幽门螺杆菌（Hp）感染和胃萎缩都是胃癌的危险因素。最近，已经发现在日本，用于胃癌筛查的X射线检查对胃癌的检出率没有太大影响。使用Hp和血清胃蛋白酶原的联合测定方法，ABC方法是一种新型的胃癌大规模筛查的候选方法，可用于鉴定高危和低危人群中胃癌的发展。建议有较高癌症风险的人接受内镜检查。 ABC法于2011年在西东京市西东京医学会的倡议下作为胃癌的大规模筛查方法进行。本文综述了使用ABC法筛查胃癌的现状，包括我们正在进行的筛查的最新结果。摘要：我们报告了2011年至2013年的36,627人的结果。其中，有16,965人接受了ABC方法的血液检查。其中8083例计划根据胃癌发生风险的分层进行内窥镜检查。实际上，共有2,911个人接受了内窥镜检查。在65例患者中检测到胃癌，其中52例（80％）被诊断为早期胃癌。 ABC方法不是有组织的筛查，而是机会性筛查。 X射线检查是同期进行的有组织的检查。使用ABC方法对1例胃癌病例的检测成本比常规X射线筛查方法便宜（（sic）1,267,452对（sic）2,807,763）。关键信息：尽管需要进一步的大规模流行病学研究，但ABC方法可能被定位为对胃癌进行有效的大规模筛查。 （C）20165。KargerAG，巴塞尔

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