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Antihistamines: a brief review

机译:抗组胺药:简要回顾

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The prevalence rates of allergic diseases such as allergic rhinitis and asthma appear to be increasing in many countries. Although several mediators are involved in the pathophysiology of allergic diseases, histamine plays a fundamental role, particularly in allergic rhinitis and urticaria. Produced and stored within the cytoplasmic granules of mast cells and basophils, histamine is released in large quantities during the immediate phase of allergic reactions.
机译:在许多国家,诸如过敏性鼻炎和哮喘等过敏性疾病的患病率似乎正在增加。尽管几种介体参与变应性疾病的病理生理,但组胺起着基本作用,特别是在变应性鼻炎和荨麻疹中。产生并储存在肥大细胞和嗜碱性粒细胞的细胞质颗粒中,组胺在过敏反应的即刻阶段大量释放。

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