Seeing red

Vivienne Baillie Gerritsen

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Seeing red

机译：见红

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The smallest of things can cause devastation. A word can hurt deeply. Distraction can create an accident. A spark can set off a fire. In the world of molecular biology, "small" rules. Life itself thrives on an intricate and very fragile harmony perpetuated by myriads of tiny molecules. And when something goes wrong, when a molecule changes its habits, it can create havoc. A few examples: cancer, Parkinson's disease, Alzheimer's and diabetes, to name but four. Blood transfusion - and even more so its effects - also depends on very small regions which themselves belong to very small molecules on the surface of each of our red blood cells. Pour the wrong kind of blood into someone, and you are in for serious complications. We all belong to a certain blood type, or group. As a consequence, we can only receive certain types of blood. Most of us have relatively common types and finding donors is usually not a problem. However, some people belong to very rare blood types, thus making blood transfusion a particularly delicate task. One of these types is known as Vel-negative. And after 60 years of scientific bafflement, it has finally been pinned down to a protein named SMIM1.

机译：最小的事物可能导致破坏。一句话会深深地伤害你。分心会造成事故。火花会引起火灾。在分子生物学世界中，“小”规则。生命本身在无数微小分子所维持的复杂而脆弱的和谐中蓬勃发展。当出现问题时，当分子改变其习性时，就会造成破坏。举几个例子：癌症，帕金森氏病，阿尔茨海默氏病和糖尿病，仅举四个例子。输血-甚至更重要的是-输血还取决于很小的区域，这些区域本身属于我们每个红细胞表面上的很小的分子。将错误的血液倒入某人中，您将面临严重的并发症。我们都属于某种血型或群体。结果，我们只能接受某些类型的血液。我们中的大多数人都具有相对常见的类型，寻找捐赠者通常不是问题。但是，有些人属于非常罕见的血液类型，因此输血是一项特别微妙的任务。这些类型之一被称为Vel-negative。经过60年的科学探索，它终于被固定在一种名为SMIM1的蛋白质上。

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《Protein Spotlight》 |2016年第1期|共页
作者
Vivienne Baillie Gerritsen;
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中图分类蛋白质（朊）化学加工工业;
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Seeing red

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