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Iodine status during pregnancy in India and related neonatal and infant outcomes

机译：印度怀孕期间的碘状况以及相关的新生儿和婴儿结局

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Abstract Objective To document iodine status in Indian pregnancies, associations with maternal diet and demographics, and offspring developmental measures. Design Longitudinal study following mothers through pregnancy and offspring up to 24 months. Setting Rural health-care centre (Vadu) and urban antenatal clinic (Pune) in the Maharashtra region of India. Subjects Pregnant mothers at 17 (n 132) and 34 weeksa€? (n 151) gestation and their infants from birth to the age of 24 months. Results Median urinary iodine concentration (UIC) was 203 and 211 ??g/l at 17 and 34 weeks of pregnancy, respectively (range 26a€“800 ??g/l). Using the UIC distribution adjusted for within-person variation, extreme UIC quartiles were compared for predictors and outcomes. There was no correlation between UIC at 17 and 34 weeks, but 24 % of those with UIC in the lowest quartile at 17 weeks had UIC in the same lowest quartile at 34 weeks. Maternal educational, socio-economic status and milk products consumption (frequency) were different between the lowest and highest quartile of UIC at 34 weeks. Selected offspring developmental outcomes differed between the lowest and highest UIC quartiles (abdominal circumference at 24 months, subscapular and triceps skinfolds at 12 and 24 months). However, UIC was only a weak predictor of subscapular skinfold at 12 months and of triceps skinfold at 24 months. Conclusions Median UIC in this pregnant population suggested adequate dietary provision at both gestational stages studied. Occasional high results found in spot samples may indicate intermittent consumption of iodine-rich foods. Maternal UIC had limited influence on offspring developmental outcomes.
机译：摘要目的记录印度孕妇的碘状况，与孕产妇饮食和人口统计学的关系以及后代的发育措施。设计纵向研究，针对母亲直至怀孕和后代长达24个月的情况。在印度马哈拉施特拉邦设立农村保健中心（Vadu）和城市产前诊所（Pune）。受试者怀孕的母亲在17（n 132）岁和34周时？ （n 151）妊娠及其婴儿从出生到24个月大。结果妊娠17周和34周尿中碘浓度（UIC）分别为203和211μg/ l（范围26a-800μg/ l）。使用针对个人差异进行调整的UIC分布，比较了极端UIC四分位数的预测变量和结果。 UIC在第17周和第34周之间没有相关性，但UIC在第17周的最低四分位数中有24％的UIC在第34周的最低四分位数中也相同。在第34周，UIC最低和最高四分位数之间的孕产妇教育，社会经济状况和乳制品消费（频率）有所不同。在UIC最低和最高四分位数之间（24个月时的腹围，12个月和24个月时的肩cap下和三头肌皮褶），选定的后代发育结果有所不同。然而，UIC只是在12个月时肩cap下皮褶和在24个月时肱三头肌皮褶的弱预测指标。结论该孕妇的UIC中位数表明在所研究的两个妊娠阶段均提供足够的饮食。斑点样品中偶尔出现的高结果可能表明间歇性食用富含碘的食物。孕产妇UIC对后代发育结局的影响有限。

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