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首页> 外文期刊>Public Health Nutrition >Antioxidant intake from diet and supplements and elevated serum C-reactive protein and plasma homocysteine concentrations in US adults: a cross-sectional study
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Antioxidant intake from diet and supplements and elevated serum C-reactive protein and plasma homocysteine concentrations in US adults: a cross-sectional study

机译：饮食和补品中抗氧化剂的摄入以及美国成年人血清C反应蛋白和血浆同型半胱氨酸浓度的升高：一项横断面研究

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ObjectiveTo investigate the association of antioxidant intakes from diet and supplements with elevated blood C-reactive protein (CRP) and homocysteine (Hcy) concentrations.DesignA cross-sectional study. The main exposures were vitamins C and E, carotene, flavonoid and Se intakes from diet and supplements. Elevated blood CRP and Hcy concentrations were the outcome measures.SettingThe US population and its subgroups.SubjectsWe included 8335 US adults aged a‰￥19 years from the National Health and Nutrition Examination Survey 1999a€“2002.ResultsIn this US population, the mean serum CRP concentration was 4?·14 (95 % CI 3?·91, 4?·37) mg/l. Intakes of vitamins C and E and carotene were inversely associated with the probability of having serum CRP concentrations >3 mg/l in multivariate logistic regression models. Flavonoid and Se intakes were not associated with the odds of elevated serum CRP concentrations. The mean plasma Hcy concentration was 8?·61 (95 % CI 8?·48, 8?·74) ??mol/l. Intakes of vitamins C, E, carotenes and Se were inversely associated with the odds of plasma Hcy concentrations >13 ??mol/l after adjusting for covariates. Flavonoid intake was not associated with the chance of elevated plasma Hcy concentrations.ConclusionsThese results suggest that high antioxidant intake is associated with lower blood concentrations of CRP and Hcy. These inverse associations may be among the potential mechanisms for the beneficial effect of antioxidant intake on CVD risk mediators in observational studies.
机译：目的探讨饮食和补品中抗氧化剂的摄入与血液中C反应蛋白（CRP）和高半胱氨酸（Hcy）浓度升高之间的关系。主要暴露于饮食和补品中的维生素C和E，胡萝卜素，类黄酮和硒的摄入量。升高的血液CRP和Hcy浓度是结果的指标。设置美国人群及其亚组。对象我们纳入了1999年至2002年美国国家健康与营养检查调查中8335位年龄≥19岁的美国成年人。结果在此美国人群中，平均血清CRP浓度为4？14（95％CI 3？91、4？37）/ l。在多元逻辑回归模型中，维生素C和E以及胡萝卜素的摄入与血清CRP浓度> 3 mg / l的可能性成反比。类黄酮和硒的摄入与血清CRP浓度升高的几率无关。血浆Hcy的平均浓度为8 9·61（95％CI 8 8·48、8 7·74）mol / l。调整协变量后，维生素C，E，胡萝卜素和Se的摄入量与血浆Hcy浓度> 13 mol / l的几率成反比。类黄酮的摄入与血浆中Hcy浓度升高的机会无关。结论这些结果表明，高抗氧化剂摄入与较低的CRP和Hcy血液浓度有关。这些相反的关联可能是观察研究中抗氧化剂摄入对CVD风险介质的有益作用的潜在机制之一。

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