A Case of Chronic Schizophrenia Who were Switched from Combined Treatment to Monotherapy and Achieved a Decrease in Positive Symptoms after Lowering the Clozapine Dose

Hayriye Dilek Hamurcu; Prof. Ali Caykoylu; Eda Peksen; Mehmet Ozturk; Neslihan Sevil

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A Case of Chronic Schizophrenia Who were Switched from Combined Treatment to Monotherapy and Achieved a Decrease in Positive Symptoms after Lowering the Clozapine Dose

机译：降低氯氮平剂量的慢性精神分裂症患者从联合治疗转为单一疗法并减少了阳性症状

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Despite the limited evidence to support the combination of antipsychotics in treatment resistant schizophrenia in the literature, this situation is common in clinical practice. Treatment guidelines recommend monotherapy for schizophrenia primarily. In this article, a chronic schizophrenic case whose treatment is changed from combination of clozapine with aripiprazole to clozapine monotherapy and whose positive symptoms decreased with the decrease of clozapine doses 900 mg/day to 625 mg/day is reported.

机译：尽管在文献中仅有有限的证据支持抗精神病药联合治疗耐药性精神分裂症，但这种情况在临床实践中很常见。治疗指南建议主要用于精神分裂症的单一疗法。本文报道了一种慢性精神分裂症病例，其治疗从氯氮平与阿立哌唑的组合改为氯氮平单药治疗，其积极症状随着氯氮平剂量从900 mg /天减少至625 mg /天而降低。

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《Psychiatry and Clinical Psychopharmacology》 |2016年第3期|共5页
作者
Hayriye Dilek Hamurcu; Prof. Ali Caykoylu; Eda Peksen; Mehmet Ozturk; Neslihan Sevil;
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中图分类临床医学;
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1. A case of chronic schizophrenia who were switched from combined treatment to monotherapy and achieved a decrease in positive symptoms after lowering the clozapine dose [J] . Hamurcu H D, Caykoylu A, Peksen E, Bulletin of Clinical Psychopharmacology . 2016,第3期

机译：一例慢性精神分裂症患者从联合治疗转为单一治疗，并在降低氯氮平剂量后阳性症状有所减轻
2. A Case Report of Chronic Schizophrenia: From Combined Treatment to Monotherapy and Decrease in Positive Symptoms with Decreasing Dose of Clozapine [J] . Yalva? H D, ?ayk?ylü A, Erkut E, Bulletin of Clinical Psychopharmacology . 2012,第Supplementa1期

机译：慢性精神分裂症的一例报告：从联合治疗到单药治疗，氯氮平剂量减少的阳性症状减少
3. A Case Report of Chronic Schizophrenia: From Combined Treatment to Monotherapy and Decrease in Positive Symptoms with Decreasing Dose of Clozapine [J] . Yalva? H D, ?ayk?ylü A, Erkut E, Bulletin of Clinical Psychopharmacology . 2012,第Supplementa1期

机译：慢性精神分裂症的一例报告：从联合治疗到单药治疗，氯氮平剂量减少的阳性症状减少
4. Developing in silico/in vitro models of schizophrenia positive symptoms [C] . Takuya Isomura, Kiyoshi Kotani, Yasuhiko Jimbo 医用?生体工学研究会 . 2015

机译：开发精神分裂症阳性症状的计算机/体外模型
5. Symptom awareness in schizophrenia: The relationship between insight into positive and /or negative symptoms and treatment compliance [D] . Leland, Rebecca Forest 2005

机译：精神分裂症的症状意识：了解阳性和/或阴性症状与治疗依从性之间的关系
6. SU114. Switching to Clozapine Treatment in Patients With Schizophrenia: The Clinical Course Remission and Augmentation of Treatment After the Switch [O] . Şevin Hun Şenol, Gamze Gürcan 2017

机译：SU114。精神分裂症患者转用氯氮平治疗：切换后的临床过程缓解和增强治疗
7. Comparison of clozapine and haloperidol effects on positive and negative symptoms of chronic schizophrenia [O] . Goodarzi I., Partovi Gh. 2005

机译：氯氮平和氟哌啶醇对慢性精神分裂症阳性和阴性症状的作用比较

A Case of Chronic Schizophrenia Who were Switched from Combined Treatment to Monotherapy and Achieved a Decrease in Positive Symptoms after Lowering the Clozapine Dose

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