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首页> 外文期刊>Psychiatry and Clinical Psychopharmacology >Total oxidant–antioxidant and paraoxonase-1 levels in premenstrual dysphoric disorder: a follow-up study
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Total oxidant–antioxidant and paraoxonase-1 levels in premenstrual dysphoric disorder: a follow-up study

机译：经前烦躁不安中的总氧化剂-抗氧化剂和对氧磷酶-1水平：一项后续研究

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Objective: Premenstrual dysphoric disorder (PMDD) is a severe form of premenstrual syndrome (PMS) that was categorized as a mood disorder in the most recent version of the Diagnostic and Statistical Manual for Mental Disorders. In addition to a history of PMS, a PMDD diagnosis requires prospective symptom assessment for 2 consecutive menstrual periods. Although the effects of some oxidants–antioxidants were previously studied in PMS, their possible effects in PMDD remain unknown. Paraoxonase-1 (PON-1) is a new high-density lipoprotein-associated enzyme with many antioxidative effects. We hypothesized that assessing serum total oxidant–antioxidant and PON-1 levels could clarify the role of oxidant–antioxidant system in PMDD.Methods: All participants (n ?=?50) were assessed by an experienced psychiatrist for PMDD by using the Diagnostic and Statistical Manual for Mental Disorders-IV (DSM-IV), Premenstrual Assessment Form and Daily Record of Severity of Problems (DRSP)-Short Form or possible psychiatric disorders including depression, anxiety, and sleep disorders. Serum estrogen, progesterone, total oxidant–antioxidant, and paraoxonase-1 (PON-1) levels were measured in the serum of 20 participants with PMDD and 30 asymptomatic controls during the follicular and luteal phases of two consecutive menstrual cycles. Sleep quality, depression, and anxiety symptoms were assessed with the Pittsburg Sleep Quality Index (PSQI), Hamilton Depression Rating Scale (HDRS), and Hamilton Anxiety Rating Scale (HARS), respectively.Results: There were no significant intergroup differences in estrogen, progesterone, oxidant–antioxidant, or PON-1 levels or PSQI scores. However, the mean HDRS and HARS scores were statistically significantly higher for patients with PMDD than for controls. Levels of estrogen, progesterone, and total oxidant–antioxidant were not correlated with HDRS, HARS, or PSQI scores.Conclusions: Considering the lack of differences in hormonal and biochemical levels between the two groups, it may be more efficient and discriminative to longitudinally assess biochemical and cellular stress-related parameters in subjects with PMDD.
机译：目的：经前烦躁不安（PMDD）是经前综合症（PMS）的一种严重形式，在最新版《精神疾病诊断和统计手册》中被归类为情绪障碍。除PMS病史外，PMDD诊断还需要连续2个月经期进行前瞻性症状评估。尽管以前曾在PMS中研究了某些氧化剂-抗氧化剂的作用，但它们在PMDD中的可能作用仍然未知。对氧磷酶-1（PON-1）是一种新型的高密度脂蛋白相关酶，具有许多抗氧化作用。我们假设评估血清总抗氧化剂和PON-1水平可以阐明氧化剂抗氧化剂系统在PMDD中的作用。方法：所有参与者（n = 50）均由经验丰富的精神病学家对PMDD进行评估。精神疾病诊断和统计手册-IV（DSM-IV），经前评估表和问题严重程度每日记录（DRSP）-简短形式或可能的精神疾病，包括抑郁症，焦虑症和睡眠障碍。在连续两个月经周期的卵泡期和黄体期，对20名患有PMDD的参与者和30名无症状对照的血清进行了血清雌激素，孕酮，总氧化剂-抗氧化剂和对氧磷酶1（PON-1）的测定。睡眠质量，抑郁和焦虑症状分别通过匹兹堡睡眠质量指数（PSQI），汉密尔顿抑郁量表（HDRS）和汉密尔顿焦虑量表（HARS）进行评估。结果：雌激素的组间差异无统计学意义，孕酮，氧化剂-抗氧化剂或PON-1水平或PSQI分数。但是，PMDD患者的HDRS和HARS平均得分在统计学上显着高于对照组。雌激素，孕酮和总氧化剂-抗氧化剂的水平与HDRS，HARS或PSQI得分无关。结论：考虑到两组之间的激素和生化水平缺乏差异，纵向评估可能更有效和更具歧视性PMDD患者的生化和细胞应激相关参数。

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