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Computational Models of the Pulmonary Circulation: Insights and the Move towards Clinically Directed Studies:

机译：肺循环的计算模型：见解和走向临床指导研究：

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摘要

Biophysically-based computational models provide a tool for integrating and explaining experimental data, observations, and hypotheses. Computational models of the pulmonary circulation have evolved from minimal and efficient constructs that have been used to study individual mechanisms that contribute to lung perfusion, to sophisticated multi-scale and -physics structure-based models that predict integrated structure-function relationships within a heterogeneous organ. This review considers the utility of computational models in providing new insights into the function of the pulmonary circulation, and their application in clinically motivated studies. We review mathematical and computational models of the pulmonary circulation based on their application; we begin with models that seek to answer questions in basic science and physiology and progress to models that aim to have clinical application. In looking forward, we discuss the relative merits and clinical relevance of computational models: what important features are still lacking; and how these models may ultimately be applied to further increasing our understanding of the mechanisms occurring in disease of the pulmonary circulation.
机译：基于生物物理的计算模型为整合和解释实验数据，观察结果和假设提供了一种工具。肺循环的计算模型已从用于研究有助于肺灌注的单个机制的最小有效结构演变为预测异质器官内整合的结构-功能关系的复杂的多尺度和基于物理结构的模型。这篇综述考虑了计算模型在提供新的见解到肺循环功能及其在临床研究中的应用方面的实用性。我们根据其应用回顾了肺循环的数学和计算模型;我们从试图回答基础科学和生理学问题的模型开始，然后发展到旨在实现临床应用的模型。展望未来，我们将讨论计算模型的相对优点和临床相关性：仍然缺少哪些重要功能;以及如何最终应用这些模型来进一步加深我们对肺循环疾病发生机理的理解。

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