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首页> 外文期刊>Quantitative Imaging in Medicine and Surgery >Quantitative CT assessment of lung injury after successful cardiopulmonary resuscitation in a porcine cardiac arrest model of different downtimes
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Quantitative CT assessment of lung injury after successful cardiopulmonary resuscitation in a porcine cardiac arrest model of different downtimes

机译：在不同停机时间的猪心脏骤停模型中，成功进行心肺复苏后肺损伤的定量CT评估

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Background: Utilize quantitative computed tomography (QCT) to detect and evaluate the severity of lung injury after successful cardiopulmonary resuscitation (CPR) in a porcine cardiac arrest (CA) model with different downtimes. Methods: Twenty-one male domestic pigs weighing 38±3 kg were randomized into 3 groups: the sham group (n=5), the ventricular fibrillation (VF) 5 min (VF5) group (n=8), and the VF 10 min (VF10) group (n=8). VF was induced and untreated for 5 (VF5 group) or 10 (VF10 group) min before the commencement of manual CPR. Eight animals (8/8, 100%) in VF5 and 6 (6/8, 75%) in VF10 were successfully resuscitated. Chest QCT scans and arterial blood gas tests were performed at baseline and 6 h post-resuscitation. The QCT score, volume, and weight of ground-glass opacification (GGO), which was defined as poorly aerated regions with a CT value ranging from ?500 Hounsfield units (HU) to ?100 HU, and intense parenchymal opacification (IPO), which was defined as a non-aerated area with a CT value greater than ?100 HU, were quantitatively measured. Results: Significantly shorter durations of CPR and fewer defibrillations were observed in the VF5 group compared with the VF10 group [duration of CPR: VF5 (6±0 minutes) versus VF10 (8.3±1.5 minutes), P0.05; numbers of defibrillation: VF5 (1±0) versus VF10 (2.2±0.8), P0.05]. Compared with the baseline or sham animals, declining gas exchanges (end-tidal CO 2 , PO 2 , oxygen index) were observed in both VF groups; however, there were no significant differences in gas exchanges between the VF groups. Compared with the VF5 group, the GGO QCT score, volume, and weight were significantly greater in the VF10 group (P=0.002, 0.001, and 0.002 respectively), while no significant differences were found in the IPO QCT score, volume, or weight between two the VF groups (P=0.354, 0.447, and 0.512 respectively). Conclusions: QCT analysis enables unique non-invasive assessments of different lung injuries (IPO and GGO lesions) that can clearly distinguish heterogeneous lesions and allow for early detection and quantitative monitoring of the severity of lung injury following CPR. QCT could provide a basis for clinical early ventilation strategy management after CPR.
机译：背景：利用定量计算机断层扫描（QCT）来检测和评估在不同停机时间的猪心跳骤停（CA）模型中成功进行心肺复苏（CPR）后肺损伤的严重程度。方法：将21只体重为38±3 kg的雄性家猪随机分为3组：假手术组（n = 5），心室颤动（VF）5分钟（VF5）组（n = 8）和VF 10最小（VF10）组（n = 8）。在开始人工心肺复苏之前，先诱发和不治疗VF 5分钟（VF5组）或10分钟（VF10组）。 VF5中的八只动物（8 / 8，100％）和VF10中的6只动物（6 / 8，75％）被成功复苏。在基线和复苏后6 h进行胸部QCT扫描和动脉血气测试。 QCT评分，体积和毛玻璃样混浊（GGO）的重量被定义为充气范围较弱的区域，CT值介于500亨斯菲尔德单位（HU）至100 HU之间，以及强烈的实质性混浊（IPO），定量地定义为CT值大于100 HU的非充气区域。结果：与VF10组相比，VF5组的CPR持续时间显着缩短，除颤次数减少[CPR持续时间：VF5（6±0分钟）vs VF10（8.3±1.5分钟），P <0.05;除颤次数：VF5（1±0）对VF10（2.2±0.8），P <0.05]。与基线动物或假动物相比，两个VF组的气体交换（潮气末CO 2，PO 2，氧指数）均下降。但是，VF组之间的气体交换没有显着差异。与VF5组相比，VF10组的GGO QCT得分，体积和重量显着更高（分别为P = 0.002、0.001和0.002），而IPO QCT得分，体积或重量没有显着差异。在两个VF组之间（分别为P = 0.354、0.447和0.512）。结论：QCT分析能够对不同的肺部损伤（IPO和GGO病变）进行独特的非侵入性评估，从而可以清楚地区分异质性病变，并允许对CPR后肺部损伤的严重程度进行早期检测和定量监测。 QCT可为心肺复苏术后临床早期通气策略管理提供基础。

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