Preparation methods, reactivity and biological importance of 4-thiazolidinones

Alves Antonio J.; Aquino Thiago M. de; Faria Ant?nio R. de; Góes Alexandre J. S.; Liesen André P.; Lima José G. de; Universidade Federal de Pernambuco Recife Brasil

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Preparation methods, reactivity and biological importance of 4-thiazolidinones

机译：4-噻唑烷酮的制备方法，反应性和生物学意义

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Molecules containing the 4-thiazolidinone ring are known to possess a wide range of biological properties including antimicrobial and anti-inflammatory activities among others. These compounds can be synthesized by cyclization reactions involving a-haloacetic acid or a-mercaptoacetic acid and employed in several chemoselective reactions. Comprehensive reviews have been written on 4-thiazolidinones in 1961 by Brown and in 1980 by Singh et al. In the recent literature, some new synthesis methods for 4-thiazolidinone derivatives and several reactions have been reported. These advances warrant to review the chemical and biological properties of compounds with this important heterocycle employed in synthetic organic chemistry and medicinal chemistry.

机译：已知含有4-噻唑烷酮环的分子具有广泛的生物学特性，包括抗微生物和抗炎活性。这些化合物可以通过涉及α-卤代乙酸或α-巯基乙酸的环化反应合成，并用于几种化学选择性反应中。布朗在1961年撰写了有关4-噻唑烷酮的综述，辛格等人在1980年发表了有关综述。在最近的文献中，已经报道了一些新的4-噻唑烷酮衍生物的合成方法和一些反应。这些进展保证了对合成有机化学和药物化学中使用的具有重要杂环的化合物的化学和生物学特性进行回顾。

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《Quimica nova》 |2008年第2期|共页
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Alves Antonio J.; Aquino Thiago M. de; Faria Ant?nio R. de; Góes Alexandre J. S.; Liesen André P.; Lima José G. de; Universidade Federal de Pernambuco Recife Brasil;
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7. Métodos de obtenção, reatividade e importância biológica de 4-tiazolidinonas Preparation methods, reactivity and biological importance of 4-thiazolidinones [O] . André P. Liesen, Thiago M. de Aquino, Alexandre J. S. Góes, 2008

机译：获得4-噻唑烷酮的方法，反应性和生物学重要性

Preparation methods, reactivity and biological importance of 4-thiazolidinones

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