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首页> 外文期刊>Ukrainian Biochemical Journal >Gentamicin and magnesium chloride normalize cholinesterase and ATPase activities in rats acutely exposed to dichlorvos (DDVP) pesticide
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Gentamicin and magnesium chloride normalize cholinesterase and ATPase activities in rats acutely exposed to dichlorvos (DDVP) pesticide

机译：庆大霉素和氯化镁使急性接触敌敌畏（DDVP）农药的大鼠的胆碱酯酶和ATPase活性正常化

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This study investigated possible use of gentamicin and magnesium chloride as antidotes of dichlorvos pesticide poisoning. Thirty albino rats were randomly divided into 5 groups ( n = 6). Group 1 served as negative control and received distilled water only. Group 2 served as positive control and was treated with 2.5 mg/kg body weight dichlorvos intraperitoneally. Group 3 was post-treated with 0.5 mg atropine following intraperitoneal 2.5 mg/kg dichlorvos while groups 4 and 5 rat were post-treated with 28 mg/kg intramuscular magnesium chloride and 5 mg/kg intramuscular gentamicin respectively following intraperitoneal 2.5 mg/kg dichlorvos. Plasma and red blood cell acetylcholinesterase activities were estimated. Total ATPase, Nasup+/sup/Ksup+/sup-ATPase, Casup2+/sup-ATPase, and Mgsup2+/sup-ATPase activities were estimated in the brain. Results showed significant ( P 2/sub and Gentamicin when compared with acetylcholinesterase activities in rats treated with dichlorvos only. There is significant ( P 2+/sup,Mgsup2+/sup-ATPases, Nasup+/sup/Ksup+/sup-ATPase and total ATPase activities in the brain of rats post treated with atropine, magnesium chloride and gentamicin. Dichlorvos significantly ( P +/sup/Ksup+/sup-ATPase and Casup2+/sup,Mgsup2+/sup-ATPases activities. Magnesium chloride and gentamicin on the other hand reduced effects of dichlorvos poisoning by promoting normal ATPase activities and inhibiting release of acetylcholine from cell. We proposed that both magnesium chloride and gentamicin can be co-administered in future as antidotes to patients with dichlorvos poisoning.
机译：这项研究调查了庆大霉素和氯化镁作为敌敌畏农药中毒解毒剂的可能用途。将三十只白化病大鼠随机分为5组（n = 6）。第1组用作阴性对照，仅接受蒸馏水。第2组用作阳性对照，并经腹膜内用2.5mg / kg体重的敌敌畏进行治疗。第3组在腹膜内注射2.5 mg / kg敌敌畏后用0.5 mg阿托品进行后处理，而第4组和第5组在腹膜内注射2.5 mg / kg敌敌畏后分别用28 mg / kg肌内氯化镁和5 mg / kg庆大霉素进行后处理。 。估计血浆和红细胞乙酰胆碱酯酶活性。总ATPase，Na + / K + -ATPase，Ca 2 + -ATPase和Mg 2 + -估计大脑中的ATPase活性。结果表明，仅在敌敌畏处理的大鼠中，与乙酰胆碱酯酶相比，显着的（P 2 和庆大霉素）。存在显着的（P 2 + ，Mg 2 + -ATPases，Na阿托品，氯化镁和庆大霉素处理后大鼠脑中 + / K + -ATPase和总ATPase活性。敌敌畏显着（P + / K + -ATPase和Ca 2 + ，Mg 2 + -ATPases活性，而氯化镁和庆大霉素则降低了敌敌畏中毒的作用我们建议，氯化镁和庆大霉素可以在将来作为敌敌畏中毒患者的解毒剂同时使用。

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