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首页> 外文期刊>Ukrainian Biochemical Journal >The features of bile acids exchange in rats under the influence of corvitin
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The features of bile acids exchange in rats under the influence of corvitin

机译：Corvitin影响下大鼠胆汁酸交换的特征

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摘要

Corvitin is a soluble form of quercetin (QUE) and its effects are based on the ability to inhibit the activity of 5-lipoxygenase and to block the formation of leukotrienes. Corvitin increases bloodflow in the stomach, pancreas and liver, but its influence on the excretory liver function has not been studied. We investigated the effect of corvitin (2.5, 5, 10 mg/kg intraportally) on bile formation, determined the biliary content of total, free and conjugated bile acids (BAs). Free and conjugated BAs were separated by thin layer chromatography method. It was shown that corvitin increased the content of total BAs in the bile of rats in all tested groups. At a dose of 2.5 mg/kg flavonoid did not сhange free BAs secretion, but while elevated the content of conjugated BAs. Both free and conjugated BAs secretion was increased in rats treated with corvitin at a dose of 5 mg/kg. Increasing of corvitin dose to 10 mg/kg resulted in enhanced secretion of free BAs. Consequently, inhibition of leukotrienes synthesis by corvitin is followed by modulation of total, free and conjugated BAs formation and secretion into the bile.
机译：Corvitin是槲皮素（QUE）的可溶形式，其作用是基于抑制5-脂氧合酶活性和阻止白三烯形成的能力。 Corvitin会增加胃，胰腺和肝脏的血流量，但尚未研究其对排泄肝功能的影响。我们调查了corvitin（2.5、5、10 mg / kg的经口胆汁）对胆汁形成的影响，确定了总胆汁，游离胆汁和共轭胆汁酸（BAs）的胆汁含量。通过薄层色谱法分离游离的和缀合的BA。结果表明，在所有测试组中，corvitin均可增加大鼠胆汁中总BAs含量。在2.5 mg / kg的剂量下，类黄酮不能抑制游离BAs的分泌，但会增加结合BAs的含量。在用5 mg / kg剂量的corvitin处理的大鼠中，游离BAs和缀合BAs的分泌均增加。 Corvitin剂量增加至10 mg / kg导致游离BAs分泌增加。因此，通过corvitin抑制白三烯合成之后，调节总的，游离的和缀合的BAs的形成以及分泌到胆汁中。

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