...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Ukrainian Biochemical Journal >Antioxidant activity of melatonin and glutathione interacting with hydroxyl- and superoxide anion radicals
【24h】

Antioxidant activity of melatonin and glutathione interacting with hydroxyl- and superoxide anion radicals

机译：褪黑素和谷胱甘肽与羟基和超氧阴离子自由基相互作用的抗氧化活性

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Based on the analysis of the results obtained by quantum chemical modeling of interaction between reduced glutathione (GSH) and melatonin (MLT) molecules with oxygen radicals (?OH and ? OOˉ) it was found that this interaction occured following the acid-base mechanism, where MLT and GSH acted as a base in respect of ?OH, and as acid in respect of ?OOˉ. We have carried out the correlation of the results of quantum chemical calculations (density redistribution, energetic characteristics) under the interaction of MLT and GSH molecules with ?OH and ?OOˉ in changing macroscopic properties of the process of electroreduction of free oxygen radicals in the presence of antioxidants (potential and maximal current wave reduction waves). This was a direct experimental macroscale evidence of the results of theoretical modeling at the nanoscale level that pointed to a marked antioxidant activity of glutathione compared with melatonin.
机译：基于对还原型谷胱甘肽（GSH）和褪黑素（MLT）分子与氧自由基（？OH和？OOˉ）相互作用的量子化学建模结果的分析，发现这种相互作用遵循酸碱机制发生，其中MLT和GSH相对于OH充当碱，相对于OO酸充当酸。在存在下改变游离氧自由基电还原过程的宏观性质的情况下，我们在MLT和GSH分子与？OH和？OOˉ相互作用下进行了量子化学计算结果（密度重新分布，能量特征）的相关性。抗氧化剂（潜在的和最大的电流减少波）。这是纳米级理论建模结果的直接实验宏观证据，表明与褪黑激素相比，谷胱甘肽具有显着的抗氧化活性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号