Distribution of glial fibrillary acidic protein in different parts of the rat brain under cadmium exposure

Yu. P. Kovalchuk; I. V. Prischepa; U. Si; V. S. Nedzvetsky

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Distribution of glial fibrillary acidic protein in different parts of the rat brain under cadmium exposure

机译：镉暴露下大鼠大脑不同部位胶质纤维酸性蛋白的分布

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The chronic effects of low doses of cadmium on the distribution of soluble and filament forms of glial fibrillary acidic protein (GFAP) and their polypeptide fragments in different parts of the rat brain were investigated. Obtained results showed dose-dependent effect of cadmium on the soluble form of GFAP and more pronounced effect on the filament form and composition of the polypeptide fragments of the protein in the rat brain. Prolonged intoxication by cadmium ions in a dose of 1.0 μg/kg of body weight induced a significant decrease in soluble GFAP and an increase in the filament form in the rat brain, pointing to the development of reactive astrogliosis and the risk of neurodegeneration.

机译：研究了低剂量镉对大鼠脑不同部位胶质原纤维酸性蛋白（GFAP）及其多肽片段的可溶性和丝状分布的慢性影响。获得的结果表明，镉对GFAP的可溶形式具有剂量依赖性，对大鼠脑中该蛋白质的多肽片段的细丝形式和组成具有更明显的影响。剂量为1.0μg/ kg体重的镉离子长期中毒诱导大鼠脑中可溶性GFAP显着降低和细丝形式增加，这表明反应性星形胶质变的发展和神经退行性变的风险。

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《Ukrainian Biochemical Journal》 |2015年第3期|共8页
作者
Yu. P. Kovalchuk; I. V. Prischepa; U. Si; V. S. Nedzvetsky;
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中图分类生物化学;
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cadmiumglial fibrillary acid proteinrat brain;

机译：镉神经胶质纤维蛋白大鼠脑;

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2. Fibrillary astrocytes proliferate in response to brain injury: A study combining immunoperoxidase technique for glial fibrillary acidic protein and radioautography of tritiated thymidine☆ [J] . Norman Latov, Gajanan Nilaver, Earl A. Zimmerman, Developmental biology . 1979,第2期

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Distribution of glial fibrillary acidic protein in different parts of the rat brain under cadmium exposure

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