Hepatoprotective activity of exogenous RNA

I. O. Shmarakov; Т. V. Marchyshak; V. L. Borschovetska

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Hepatoprotective activity of exogenous RNA

机译：外源RNA的保肝活性

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Hepatoprotective activity of Nuclex, a pharmaceutical composed of low-molecular yeast RNA, was investigated during acute and chronic thioacetamide-induced hepatotoxicity. It is demonstrated, that Nuclex administration at a dose of 200 mg/kg during acute and chronic liver injury produces hepatoprotective effect, which is associated with decrease in liver parenchyma lesions and in its inflammatory infiltration. Nuclex application attenuates thioacetamide-induced free radical damage of hepatic biopolymers, expressed in the reduction of TBA-reactive products, carbonyl derivatives, and recovery of protein thiol groups and reduced glutathione levels.

机译：在急性和慢性硫代乙酰胺诱导的肝毒性过程中，研究了由低分子酵母RNA组成的药物Nuclex的保肝活性。已经证明，在急性和慢性肝损伤期间以200 mg / kg的剂量施用Nuclex可产生保肝作用，其与肝实质损伤及其炎性浸润的减少有关。 Nuclex的应用减轻了硫代乙酰胺对肝生物聚合物的自由基损伤，表现为TBA反应产物，羰基衍生物的减少以及蛋白质硫醇基团的回收和谷胱甘肽水平的降低。

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《Ukrainian Biochemical Journal》 |2015年第4期|共8页
作者
I. O. Shmarakov; Т. V. Marchyshak; V. L. Borschovetska;
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中图分类生物化学;
关键词
C57BL6/J micehepatoprotective effect of exogenous RNAhepatotoxicityNuclexthioacetamide;

机译：C57BL6 / J外源RNA的小鼠肝保护作用肝毒性核酸硫代乙酰胺。;

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Hepatoprotective activity of exogenous RNA

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