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首页> 外文期刊>Upsala journal of medical sciences >Cancer of the Stomach after Operation for Benign Ulcer Disease
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Cancer of the Stomach after Operation for Benign Ulcer Disease

机译：良性溃疡病手术后胃癌

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Despite a great number of studies during almost three decades it has not been possible to satisfactorily answer the question how the risk of developing cancer of the stomach is affected by operation for ulcer disease. The answer to this question is interesting from a tumourbiological point of veiw and practically important when choosing treatment and follow-up routines. In principle this can be said to be a test case for clinical problems that can be solved most effectively by epidemiological research methods. In this brief survey are summarized first the state of knowledge in the field and the methodological problems that have made it hard to study the question. Then a historical cohort study is reported which has just been finished in the health care region of Uppsala. By following a sufficiently great number of individuals (fully 6,000) over a long time (25–33 years) and using multi-variate methods of analysis it was possible to demonstrate a consistent and complex pattern of a changed risk of cancer of the stomach after partial gastrectomy according to Billroth I and II. Not only the choice of surgical method influences this risk but also age at operation, diagnosis, the length of the observational follow-up, and the sex of the patient.
机译：尽管在近三十年中进行了大量研究，但仍无法令人满意地回答溃疡病手术如何影响患胃癌的风险这一问题。从肿瘤生物学的角度来看，这个问题的答案很有趣，在选择治疗方法和随访程序时实际上很重要。原则上，这可以说是临床问题的测试案例，可以通过流行病学研究方法最有效地解决。在此简短的调查中，首先总结了该领域的知识状态以及使该问题难以研究的方法论问题。然后报道了一项历史队列研究，该研究刚刚在乌普萨拉的医疗保健地区完成。通过长期（25-33年）追踪足够多的个体（总共6,000名）并使用多变量分析方法，有可能证明一致和复杂的模式改变了胃癌术后胃癌的风险根据Billroth I和II进行部分胃切除术。不仅手术方法的选择会影响这种风险，而且还会影响手术的年龄，诊断，观察随访的时间以及患者的性别。

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