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首页> 外文期刊>Upsala journal of medical sciences >Cigarette smoke and hypoxia induce acute changes in testicular and celebral microcirculation
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Cigarette smoke and hypoxia induce acute changes in testicular and celebral microcirculation

机译：香烟烟雾和缺氧引起睾丸和脑微循环的急性变化

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The acute effects of cigarette smoking and hypoxia on the cerebral and testicular microcirculation were studied in anestethised adult rats. Smoking for 2 min did not influence arterial pO2, pCO2 or pH but it induced an increase in cerebral blood flow by 34% and inhibited vasomotion in the testis for about 1 h. One hour after smoke exposure apnea induced a slight increase in arterial pCO2, a significant decrease in pO2, and an increase in cerebral blood flow (CBF) by 54%. In animals not previously exposed to cigarette smoke apnea increased CBF by 121%, demonstrating that a short-term exposure to tobacco smoke influences the cerebrovascular reactivity for more than one hour. In the testis, apnea resulted in a decreased blood flow by 39% and a complete depression of vasomotion. Breathing 10% O2/90% N2 resulted in moderate hypoxia, a total disappearance of the vasomotion in the testis, a 24% decrease in testicular blood flow, but a 23% increase in CBF. Our results indicate that short- term exposure to tobacco smoke induces marked acute vascular effects in both the brain and the testis. Apnea and moderate hypoxia elicted totally differnt effect in the brain and testis, indicating different vascular control mechanisms.
机译：在成年大鼠中研究了吸烟和缺氧对大脑和睾丸微循环的急性影响。吸烟2分钟不会影响动脉pO 2 ，pCO 2 或pH值，但会引起脑血流量增加34％，并抑制睾丸中的血管运动约1倍。 H。暴露于烟雾的一小时后，呼吸暂停导致动脉pCO 2 略有增加，pO 2 显着降低，脑血流量（CBF）增加了54％。在以前未接触过香烟烟雾呼吸暂停的动物中，CBF增加了121％，这表明短期接触烟草烟雾会影响脑血管反应超过一小时。在睾丸中，呼吸暂停导致血液流量减少39％，血管运动完全降低。呼吸10％O2 / 90％N 2 会导致中度缺氧，睾丸血管运动完全消失，睾丸血流量减少24％，而CBF增加23％。我们的结果表明，短期接触烟草烟雾会在大脑和睾丸中引起明显的急性血管效应。呼吸暂停和中度缺氧在大脑和睾丸中引起完全不同的作用，表明不同的血管控制机制。

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