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首页> 外文期刊>Taiwanese journal of obstetrics and gynecology >Could serum levels of irisin be used in gestational diabetes predicting?
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Could serum levels of irisin be used in gestational diabetes predicting?

机译：血清鸢尾素水平可用于妊娠糖尿病的预测吗？

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ObjectiveGestational diabetes mellitus (GDM) is a metabolic disorder during pregnancy leading to acute and chronic complications in both mother and newborn. The pathogenesis of GDM has not been fully understood, However, since the disease shares risk factors with type 2 diabetes mellitus (T2DM), a relationship between these two disease states is plausible. The recently discovered peptide irisin has been hypothesized to be a regulator of body metabolism. However, studies ended up with controversial results. In the present study, we aimed to investigate the relationship between irisin levels and gestational diabetes mellitus and the possible benefits of the metabolic profile.Materials and methodsWe performed a cross-sectional analysis of circulating levels of irisin in 100 pregnant women similar for age and body mass index and the groups included 50 gestational diabetic patients and 50 healthy pregnant volunteers. Serum irisin levels were measured by ELISA kit.ResultsMean age and body mass index levels were similar in both groups. Median HbA1c, fasting blood glucose, Glucose 1?h, Glucose 2?h and fasting insülin levels were higher in with gestational diabetic patients compared to the control group. In gestational diabetic group, the median irisin level was lower than in the control group.ConclusionSerum irisin levels were lower in gestational diabetic patients. Further investigations are needed to explore the underlying biological effects of irisin on pregnant women.
机译：目的妊娠期糖尿病（GDM）是妊娠期间的代谢异常，导致母亲和新生儿的急性和慢性并发症。 GDM的发病机理尚未完全了解，但是，由于该疾病与2型糖尿病（T2DM）共享危险因素，因此这两种疾病状态之间的关系是合理的。据推测，最近发现的肽鸢尾素是身体代谢的调节剂。但是，研究最终产生了有争议的结果。在本研究中，我们旨在研究鸢尾素水平与妊娠糖尿病之间的关系以及代谢谱的可能益处。材料和方法我们对100名年龄和身体相似的孕妇进行了鸢尾素循环水平的横断面分析。质量指数，该组包括50名妊娠糖尿病患者和50名健康怀孕志愿者。用ELISA试剂盒测定血清虹膜素水平。结果两组的平均年龄和体重指数水平相似。与对照组相比，妊娠糖尿病患者的中位HbA1c，空腹血糖，葡萄糖1？h，葡萄糖2？h和空腹胰岛素水平更高。妊娠糖尿病组的中值鸢尾素水平低于对照组。结论妊娠糖尿病患者的血清中鸢尾素水平较低。需要进一步的研究以探索鸢尾素对孕妇的潜在生物学作用。

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