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首页> 外文期刊>Taiwanese journal of obstetrics and gynecology >Application of non-invasive detection of peripheral vascular dysfunction in ovarian hyperstimulation syndrome (OHSS): A pilot study of clinical relevance
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Application of non-invasive detection of peripheral vascular dysfunction in ovarian hyperstimulation syndrome (OHSS): A pilot study of clinical relevance

机译：无创检测外周血管功能障碍在卵巢过度刺激综合征（OHSS）中的应用：临床意义的初步研究

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ObjectiveThe current study tested the hypothesis that vascular endothelial function, as reflected by the reactive hyperemia index (RHI), and biochemical factors, including VEGF, TNFα, CRP, inhibin A, and inhibin B, were involved in the pathogenesis of ovarian hyperstimulation syndrome (OHSS).Materials and methodsThis study was conducted between June 2010 and June 2012, enrolling 15 patients with OHSS and 6 healthy control subjects <45 years of age. Detailed clinical parameters were reviewed, including serum VEGF, TNFα, CRP, inhibin A, inhibin B, and hematocrit. RHI assessed by novel automatic peripheral arterial tonography was used to evaluate the vascular endothelial function.ResultsTwenty-one subjects were evaluated. There was no significant difference between patients with OHSS and control subjects with respect to VEGF, TNFα, CRP, inhibin A and inhibin B. The RHI was not significantly different between patients with OHSS and control subjects (mean, 1.8?±?0.4 vs. 1.7?±?0.2). The hematocrit was significantly different between patients with OHSS and control subjects.ConclusionsOur preliminary data did not reveal direct evidence of vascular endothelial dysfunction in patients with OHSS. To identify whether RHI could reflect vascular endothelial dysfunction in patients with OHSS, more cases with different severities of OHSS should be recruited in the future study.
机译：目的本研究检验了以下假设：反应性充血指数（RHI）反映了血管内皮功能以及包括VEGF，TNFα，CRP，抑制素A和抑制素B在内的生化因素参与了卵巢过度刺激综合征的发病机制（ OHSS）。材料与方法本研究于2010年6月至2012年6月进行，招募了15例OHSS患者和6名45岁以下的健康对照者。审查了详细的临床参数，包括血清VEGF，TNFα，CRP，抑制素A，抑制素B和血细胞比容。应用新型自动外周动脉造影对RHI进行评估，以评估其血管内皮功能。结果对21名受试者进行了评估。在OHSS患者和对照组之间，就VEGF，TNFα，CRP，抑制素A和抑制素B而言，无显着差异。在OHSS患者和对照组之间，RHI差异不显着（平均值为1.8±0.4。 1.7≤±0.2）。结论OHSS患者与对照组患者的血细胞比容显着不同。结论我们的初步数据并未揭示OHSS患者血管内皮功能障碍的直接证据。为了确定RHI是否可以反映OHSS患者的血管内皮功能障碍，在以后的研究中应招募更多具有不同严重程度OHSS的病例。

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