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首页> 外文期刊>Pathology and Laboratory Medicine International >Occult hepatitis B virus infection in Egyptian hemodialysis patients with or without hepatitis C virus infection
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Occult hepatitis B virus infection in Egyptian hemodialysis patients with or without hepatitis C virus infection

机译：埃及血液透析患者是否伴有丙型肝炎病毒隐匿性乙型肝炎病毒感染

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Abstract: Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are frequent in patients with end-stage renal disease who are on maintenance hemodialysis. There are limited data about the prevalence of occult HBV infection in patients on long-term hemodialysis. Occult HBV is defined as positive HBV DNA in the blood in the absence of hepatitis B surface -antigen in the serum. In this study, we determined the prevalence of occult HBV in hemodialysis patients with or without HCV infection. The study included 116 patients with end-stage renal disease on chronic hemodialysis, of whom 64 patients were HCV RNA positive (Group 1), and 52 were HCV RNA negative (Group 2). We found that four of 64 (6.3%) hemodialysis patients with HCV infection (Group 1) had occult HBV, while only two of 52 (3.8%) hemodialysis patients without HCV (Group 2) had occult HBV. We then examined whether gender-matched -hemodialysis patients with positive HBV DNA in the two hemodialysis groups differed in specific parameters, ie, age, degree of liver dysfunction, and presence of -coinfection with schistosomiasis, a common parasitic infection of the liver. We found no significant difference between the groups having positive HBV DNA with regard to serum levels of liver enzymes, aspartate transaminase, albumin, and hepatitis B core antigen (P > 0.05). However, we detected significantly higher levels of alanine transaminase, a prolonged duration of hemodialysis, and higher levels of schistosomal antibodies in Group 1 than in Group 2. Interestingly, we found that the presence of schistosomal antibodies, history of past blood transfusion, and longer hemodialysis -duration could distinguish patients with occult HBV infection from those with HBV DNA negative infection in hemodialysis patients. In conclusion, the prevalence of occult HBV in chronic hemodialysis patients is low, and does not significantly differ between hemodialysis patients with or without HCV coinfection.
机译：摘要：维持性血液透析的终末期肾脏疾病患者经常感染乙型肝炎病毒（HBV）和丙型肝炎病毒（HCV）。关于长期血液透析患者隐匿性HBV感染患病率的数据有限。隐匿性HBV定义为在血清中不存在乙型肝炎表面抗原的情况下血液中的阳性HBV DNA。在这项研究中，我们确定了有或没有HCV感染的血液透析患者的隐匿性HBV患病率。该研究纳入了116例患有慢性血液透析的终末期肾脏疾病的患者，其中64例HCV RNA阳性（第1组），52例HCV RNA阴性（第2组）。我们发现64例（6.3％）HCV感染的血液透析患者（第1组）有隐匿性HBV，而52例（3.8％）无HCV的血液透析患者（第2组）中只有2例隐匿HBV。然后，我们检查了两个血液透析组中具有性别匹配的HBV DNA阳性的血液透析患者在特定参数方面是否存在差异，例如年龄，肝功能障碍程度以及血吸虫病的合并感染，血吸虫病是肝脏的常见寄生虫感染。我们发现，在HBV DNA阳性的组之间，肝酶，天冬氨酸转氨酶，白蛋白和乙型肝炎核心抗原的血清水平没有显着差异（P> 0.05）。但是，我们发现第1组的丙氨酸转氨酶水平，血液透析时间延长以及血吸虫抗体水平明显高于第2组。有趣的是，我们发现血吸虫抗体的存在，过去的输血史以及更长的时间血液透析持续时间可以将隐性HBV感染患者与HBV DNA阴性感染患者区分开。总之，在慢性血液透析患者中​​隐匿性HBV的患病率较低，并且在有或没有HCV合并感染的血液透析患者之间无明显差异。

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