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首页> 外文期刊>Polymer Sciences >Preparation of Nano Triblock Co-polymer for Desferoxiamine Delivery and Cross-Linked Copolymer for Iron Overload Disease
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Preparation of Nano Triblock Co-polymer for Desferoxiamine Delivery and Cross-Linked Copolymer for Iron Overload Disease

机译：制备用于去铁胺的纳米三嵌段共聚物和用于铁超载疾病的交联共聚物

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Some IPNs and copolymer were prepared at different ratios from bisacryl amide as crosslinking agent by Redox polymerization. These IPNs (polyacrylamide –poly ethylene imine); (polyacrylamide-poly electrolyte) and poly (acrylamide-acrylic acid) copolymer are examined by UV-VIS spectrophotometry method to determine their ability for linking with iron ions that are prepared with standard solution employed for this purpose. The results, indicate that the copolymer prepared from (AcAm:AcAc) with 20% (wt/wt) from bisacrylamide has the ability of removing the iron ions from the solution. The swelling ratio for the prepared IPNs and copolymers was studied as a function of time at different pH (1.2, 8.4) and distilled water; the obtained data show that the swelling ratio was increased with increasing the pH. The morphology of copolymers was performed by scanning electron microscopy (SEM) to show the pore size. A new triblock copolymer of (Polylactide-Pluronic127-Polylactide) is synthesized by ring opening polymerization using (DUB) Diazabicyclo-[5.4.0]-udec-7-ene as a catalyst. The triblock copolymer is characterized 1HNMR. Semi IPNs from triblock copolymer with acrylamide was prepared to use as a polymer drug delivery with Desferriox aminemethanesulphate (Iron overload chelating drug). The SEM for this semi IPN shows the nano structure due to the regular orientation of lactide fibers. Desferoxiamine release study as a function of time at pH 1.2 and 8.4 for 24 hours with semi IPNs coated with tetramethylourea and without coating was also carried out. The releasing studies show that the rate of releasing at GIF is larger than SGF.
机译：以双丙烯酰胺为交联剂，通过氧化还原聚合反应制备了一些不同比例的IPN和共聚物。这些IPN（聚丙烯酰胺-聚乙烯亚胺）;通过UV-VIS分光光度法检查（聚丙烯酰胺-聚电解质）和聚（丙烯酰胺-丙烯酸）共聚物，以确定它们与铁离子连接的能力，该铁离子用为此目的使用的标准溶液制备。结果表明，由（AcAm：AcAc）与20％（wt / wt）的双丙烯酰胺制备的共聚物具有从溶液中去除铁离子的能力。研究了在不同的pH（1.2，8.4）和蒸馏水条件下，制备的IPN和共聚物的溶胀率随时间的变化。所得数据表明溶胀率随pH值的增加而增加。共聚物的形态通过扫描电子显微镜（SEM）进行以显示孔径。通过使用（DUB）二氮杂双环-[5.4.0] -udec-7-烯作为催化剂通过开环聚合合成（Polylactide-Pluronic127-Polylactide）的新型三嵌段共聚物。该三嵌段共聚物的特征在于1 HNMR。由三嵌段共聚物与丙烯酰胺制备的半IPN可以与Desferriox胺甲烷硫酸盐（铁超载螯合剂）一起用作聚合物药物递送。由于丙交酯纤维的规则取向，该半IPN的SEM显示出纳米结构。在半IPNs涂有四甲基脲的情况下和不涂膜的情况下，在pH 1.2和8.4的条件下进行了去铁氧胺释放随时间变化的研究24小时。释放研究表明，GIF的释放速率大于SGF。

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