Graphical '/> Facile preparation of core cross-linked nanomicelles based on graft copolymers with pH responsivity and reduction sensitivity for doxorubicin delivery
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Facile preparation of core cross-linked nanomicelles based on graft copolymers with pH responsivity and reduction sensitivity for doxorubicin delivery

机译：基于接枝共聚物的核心交联纳米钙的容纳制备，具有pH响应性和减少多柔比星输送的敏感性

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Graphical abstractDisplay OmittedHighlights?DOX-loaded core cross-linked nanomicelles with dual-sensitivity were fabricated.?Drug release of DOX-loaded micelles was triggered in the tumor microenvironment.?DOX-loaded micelles showed enhanced cellular uptake.AbstractTo achieve passive targeting and controlled drug release at tumor sites trigged by low pH value and high level of glutathione (GSH), optimized delivery system for doxorubicin (DOX) based on core cross-linked nanomicelles was developed in this research. Particularly, methoxypoly(ethylene glycol)-nitrophenyl carbonate (mPEG-NPC) and 3,4-dihydroxyphenylaceticacid were grafted onto synthesized poly(N,N′-cystamine bisacrylami
机译：<！[cdata [ 图形抽象 显示省略 突出显示 ？ 用双敏感性的Dox加载的核心交联纳米钙。 ？ 在TU中触发了Dox加载胶束的药物释放Mor MicroEnvironment。 ？ 装载的Dox加载胶束显示出增强的蜂窝摄取。 抽象 在肿瘤部位实现被动靶向和受控药物释放，延迟低pH值和高水平的谷胱甘肽（GSH），优化的递送系统对于基于核心交联的纳米测定的多柔比星（DOX）在本研究中开发。特别是，将甲氧基聚苯酯（乙二醇） - 碳酸酯（MPEG-NPC）和3,4-二羟基苯基乙酸酸接枝到合成的聚（ n，n' -cystamine bisacrylami

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  • 作者

    Tiandong Chen; Yi Xiao; Wei Lu; Shiyuan Liu; Lin Gan; Jiahui Yu; Jin Huang;

  • 作者单位

    Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development School of Chemistry and Molecular Engineering East China Normal University;

    Department of Radiology and Nuclear Medicine Changzheng Hospital Naval Medical University;

    Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development School of Chemistry and Molecular Engineering East China Normal University;

    Department of Radiology and Nuclear Medicine Changzheng Hospital Naval Medical University;

    School of Chemistry and Chemical Engineering Southwest University;

    Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development School of Chemistry and Molecular Engineering East China Normal University;

    School of Chemistry and Chemical Engineering Southwest University;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 胶体化学（分散体系的物理化学）;
  • 关键词

    pH Responsivity; Reduction sensitivity; Fe3+-catechol complex; Core cross-linked micelles;

    机译：pH响应性;减少灵敏度;Fe3 + -Catechol复合物;核心交联胶束;
  • 入库时间 2022-08-19 23:58:28

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