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首页> 外文期刊>Polymer Sciences >Preparation and Release Study of Biodegradable L-lactide IPNa??s Insulin Delivery
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Preparation and Release Study of Biodegradable L-lactide IPNa??s Insulin Delivery

机译：可生物降解的L-丙交酯IPNa胰岛素递送的制备与释放研究

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Novel triblock copolymers of poly(L-lactide)-poly(ethylene glycol)-sebacate-poly(ethylene glycol)-poly(L-lactide) were synthesized by Ring-Opening Polymerization (ROP) of different ratios of L-lactide with three pre-prepared poly(ethylene glycol)-sebacate-poly(ethylene glycol) polymers A, B and C have different poly(ethylene glycol) molecular weight (2000, 4000, and 10000 g/mole). The triblock copolymers were used to produce nine triblock copolymers having new different lactide chain length (n=10, 25 and 50), coded AL10, AL25, AL50, BL10, BL25, BL50, CL10, CL25, and CL50, respectively. Nine networks were prepared from triblock copolymers with cross-linked sodium alginate, S1-S9. All those polymer networks were loaded with 50 IU of insulin. Each component of the polymer network groups was mixed with cross-linked hydroxyl ethyl cellulose to form SH1-SH9 from S1-S9 fiber IPN’s. These samples were coated with gelatin cross-linked with two different ratios of gluteraldehyde, 20% and 40% w/w by one layer and two layers. Insulin release study at pH 1.2 and 8.4 for 24 hours was performed. Hydrolytic degradation studies were followed at three different pH, 1.2, 7 and 8.4 for 7 weeks with 40% as maximum degradation.
机译：通过不同比例的L-丙交酯与三种比例的开环聚合（ROP）合成了聚（L-丙交酯）-聚（乙二醇）-癸二酸酯-聚（乙二醇）-聚（L-丙交酯）的新型三嵌段共聚物预先制备的聚（乙二醇）-癸二酸酯-聚（乙二醇）聚合物A，B和C具有不同的聚（乙二醇）分子量（2000、4000和10000 g / mol）。三嵌段共聚物用于生产九种具有新的不同丙交酯链长（n = 10、25和50）的三嵌段共聚物，分别编码为AL10，AL25，AL50，BL10，BL25，BL50，CL10，CL25和CL50。由三嵌段共聚物与交联的藻酸钠S1-S9制备九个网络。所有这些聚合物网络都装有50 IU胰岛素。将聚合物网络组的每个组分与交联的羟乙基纤维素混合，以由S1-S9纤维IPN形成SH1-SH9。这些样品涂有一层和两层交联的明胶，该明胶用两种不同比例的戊二醛（20％和40％w / w）交联。在pH 1.2和8.4下进行了24小时的胰岛素释放研究。在三种不同的pH值（1.2、7和8.4）下进行水解降解研究7周，最大降解率为40％。

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