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首页> 外文期刊>Polymers >Additive Manufacturing of Nerve Decellularized Extracellular Matrix-Contained Polyurethane Conduits for Peripheral Nerve Regeneration
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Additive Manufacturing of Nerve Decellularized Extracellular Matrix-Contained Polyurethane Conduits for Peripheral Nerve Regeneration

机译：用于周围神经再生的神经脱细胞的细胞外基质基质聚氨酯导管的增材制造

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The nervous system is the part of our body that plays critical roles in the coordination of actions and sensory information as well as communication between different body parts through electrical signal transmissions. Current studies have shown that patients are likely to experience a functional loss if they have to go through a nerve repair for 15 mm lesion. The ideal treatment methodology is autologous nerve transplant, but numerous problems lie in this treatment method, such as lack of harvesting sites. Therefore, researchers are attempting to fabricate alternatives for nerve regeneration, and nerve conduit is one of the potential alternatives for nerve regeneration. In this study, we fabricated polyurethane/polydopamine/extracellular matrix (PU/PDA/ECM) nerve conduits using digital light processing (DLP) technology and assessed for its physical properties, biodegradability, cytocompatibility, neural related growth factor, and proteins secretion and expression and its potential in allowing cellular adhesion and proliferation. It was reported that PU/PDA/ECM nerve conduits were more hydrophilic and allowed enhanced cellular adhesion, proliferation, expression, and secretion of neural-related proteins (collagen I and laminin) and also enhanced expression of neurogenic proteins, such as nestin and microtubule-associated protein 2 (MAP2). In addition, PU/PDA/ECM nerve conduits were reported to be non-cytotoxic, had sustained biodegradability, and had similar physical characteristics as PU conduits. Therefore, we believed that PU/PDA/ECM nerve conduits could be a potential candidate for future nerve-related research or clinical applications.
机译：神经系统是人体的一部分，在协调动作和感官信息以及通过电信号传输的不同身体部位之间的通信中起着至关重要的作用。当前的研究表明，如果患者必须进行神经修复以治疗大于15毫米的病灶，则可能会出现功能丧失。理想的治疗方法是自体神经移植，但是这种治疗方法存在很多问题，例如缺乏收获部位。因此，研究人员正在尝试制造神经再生的替代方法，而神经导管是神经再生的潜在替代方法之一。在这项研究中，我们使用数字光处理（DLP）技术制造了聚氨酯/聚多巴胺/细胞外基质（PU / PDA / ECM）神经导管，并对其物理性质，生物降解性，细胞相容性，神经相关生长因子以及蛋白质分泌和表达进行了评估及其在细胞粘附和增殖中的潜力。据报道，PU / PDA / ECM神经导管具有更强的亲水性，可以增强神经相关蛋白（胶原蛋白I和层粘连蛋白）的细胞粘附，增殖，表达和分泌，还可以增强巢蛋白和微管等神经源蛋白的表达。 -相关蛋白2（MAP2）。此外，据报道，PU / PDA / ECM神经导管无细胞毒性，具有持续的生物降解能力，并且具有与PU导管相似的物理特性。因此，我们认为PU / PDA / ECM神经导管可能是未来神经相关研究或临床应用的潜在候选者。

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