...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neural regeneration research >Decellularized sciatic nerve matrix as a biodegradable conduit for peripheral nerve regeneration
【24h】

Decellularized sciatic nerve matrix as a biodegradable conduit for peripheral nerve regeneration

机译：脱细胞坐骨神经基质作为外周神经再生的可生物降解导管

获取原文
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The use of autologous nerve grafts remains the gold standard for treating nerve defects, but current nerve repair techniques are limited by donor tissue availability and morbidity associated with tissue loss. Recently, the use of conduits in nerve injury repair, made possible by tissue engineering, has shown therapeutic potential. We manufactured a biodegradable, collagen-based nerve conduit containing decellularized sciatic nerve matrix and compared this with a silicone conduit for peripheral nerve regeneration using a rat model. The collagen-based conduit contains nerve growth factor, brain-derived neurotrophic factor, and laminin, as demonstrated by enzyme-linked immunosorbent assay. Scanning electron microscopy images showed that the collagen-based conduit had an outer wall to prevent scar tissue infiltration and a porous inner structure to allow axonal growth. Rats that were implanted with the collagen-based conduit to bridge a sciatic nerve defect experienced significantly improved motor and sensory nerve functions and greatly enhanced nerve regeneration compared with rats in the sham control group and the silicone conduit group. Our results suggest that the biodegradable collagen-based nerve conduit is more effective for peripheral nerve regeneration than the silicone conduit.
机译：自体神经移植物的使用仍然是治疗神经缺损的金标准，但当前的神经修复技术受到供体组织可用性和与组织丢失相关的发病率的限制。最近，通过组织工程使导管在神经损伤修复中的使用已显示出治疗潜力。我们制造了一种可生物降解的，基于胶原蛋白的神经导管，其中含有脱细胞的坐骨神经基质，并将其与使用大鼠模型的用于周围神经再生的硅树脂导管进行了比较。基于胶原的导管包含神经生长因子，脑源性神经营养因子和层粘连蛋白，如酶联免疫吸附试验所证实。扫描电子显微镜图像显示，基于胶原的导管具有防止疤痕组织浸润的外壁和允许轴突生长的多孔内部结构。与假对照组和硅胶导管组相比，植入胶原蛋白导管弥合坐骨神经缺损的大鼠的运动和感觉神经功能明显改善，神经再生大大增强。我们的结果表明，可生物降解的基于胶原的神经导管比硅树脂导管更有效地促进周围神经再生。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号