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首页> 外文期刊>Taiwanese journal of obstetrics and gynecology >Low plasma levels of decoy receptor 3 (DcR3) in the third trimester of pregnancy with preeclampsia
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Low plasma levels of decoy receptor 3 (DcR3) in the third trimester of pregnancy with preeclampsia

机译：子痫前期妊娠晚期的诱饵受体3（DcR3）血浆水平低

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ObjectiveThe pathophysiology of preeclampsia, a major threat during pregnancy characterized by excessive inflammatory status, remains unclear. Decoy receptor 3 (DcR3), a soluble member of the tumor necrosis factor receptor (TNFR) superfamily, is capable of inducing anti-apoptosis via binding with TL1A and anti-inflammation by driving Th2 immune reactions. DcR3 may, therefore, play a role in immune modulation during pregnancy. The purpose of this study is to explore the role of DcR3 in normal and preeclamptic pregnancies.Materials and methodsPlasma samples from 104 normal pregnant women (26, 42, and 36 in the first, second, and third trimester, respectively) and 10 patients with preeclampsia in the third trimester were collected. Plasma DcR3 levels were determined by using commercial ELISA kits. ANOVA and linear regression analysis were performed to analyze the relationship between gestational age and DcR3 levels. After adjusting for gestational days, the levels of plasma DcR3 in preeclamptic and non-preeclamptic women in the third trimester were compared.ResultsThe plasma levels of DcR3 gradually decreased as the gestational days increased during pregnancy (p?
机译：目的子痫前期的病理生理学尚不清楚，妊娠前的主要威胁是炎症状态过多。诱饵受体3（DcR3）是肿瘤坏死因子受体（TNFR）超家族的可溶性成员，能够通过与TL1A结合诱导抗凋亡，并通过驱动Th2免疫反应来抗炎。因此，DcR3可能在怀孕期间发挥免疫调节作用。本研究的目的是探讨DcR3在正常和先兆子痫妊娠中的作用。材料和方法从104名正常孕妇（分别在孕中期，孕中期和孕中期分别为26、42和36）和10例孕妇中的血浆样本收集妊娠中期的先兆子痫。血浆DcR3水平通过使用商业ELISA试剂盒测定。进行方差分析和线性回归分析以分析胎龄与DcR3水平之间的关系。调整妊娠天数后，比较妊娠中期和非先兆子痫妇女的血浆DcR3水平。结果随着妊娠期间妊娠天数的增加，血浆DcR3水平逐渐降低（p <0.05）。在妊娠中期，先兆子痫孕妇的血浆DcR3水平明显低于非先兆子痫的女性（p <0.05）。结论我们发现随着妊娠的进行，血浆DcR3水平逐渐降低。子痫前期妇女的血浆DcR3水平显着低于正常孕妇，表明DcR3可能参与正常妊娠和DcR3水平降低可能与子痫前期有关。

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