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首页> 外文期刊>Urology Annals >The effects of combined free radical scavenger and sildenafil therapy on age-associated erectile dysfunction: An animal model
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The effects of combined free radical scavenger and sildenafil therapy on age-associated erectile dysfunction: An animal model

机译：自由基清除剂和西地那非联合治疗对与年龄相关的勃起功能障碍的影响：一种动物模型

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Introduction: Aging results in erectile dysfunction that is partially attributed to decreased nitric oxide (NO) and increased free radical generation. Vitamin E enhances endothelial cell function and acts as a free radical scavenger; however, its benefits on erectile function in the elderly are unknown. Aims: The aim of the following study is to determine if Vitamin E alone, or in combination with the phosphodiesterase 5 inhibitor sildenafil, may improve erectile function and the NO signaling in a cohort of aged (13-15 month old) rats. Materials and Methods: Male Sprague-Dawley rats (n = 28) were divided based upon age into young (4-5 months old, n = 7) and aged (13-15 months old, n = 21) cohorts. Aged rats were treated with Vitamin E, sildenafil or a combination of both. Penile cavernosal and dorsal nerve tissues were evaluated for neuronal nitric oxide synthase (nNOS) and caveolin-1 expression. Erectile function was assessed through intra-cavernous pressure (ICP) recordings. Results: nNOS and cavoelin-1 were significantly decreased in aged rats compared with young controls. In aged rats, both Vitamin E and sildenafil partially recovered nNOS expression but when combined, a synergistic elevation in nNOS was observed. The significant decreases in ICP recorded in aged rats were improved with sildenafil; however, Vitamin E did not yield any additional improvements in ICP. Conclusions: Diminished levels of nNOS and caveolin-1 are found in aged rats. When combined with sildenafil, Vitamin E synergistically increased nNOS expression. Since biochemical gains were not realized physiologically, other contributing factors likely exist.
机译：简介：衰老导致勃起功能障碍，部分原因是一氧化氮（NO）减少和自由基生成增加。维生素E增强内皮细胞功能并充当自由基清除剂。但是，它对老年人勃起功能的益处尚不清楚。目的：以下研究的目的是确定单独的维生素E或与磷酸二酯酶5抑制剂西地那非联合使用是否可以改善年龄较大（13-15个月大）大鼠的勃起功能和NO信号传导。材料和方法：将雄性Sprague-Dawley大鼠（n = 28）根据年龄分为年轻（4-5个月大，n = 7）和年龄（13-15个月大，n = 21）。用维生素E，西地那非或两者的组合治疗老年大鼠。评估阴茎海绵体和背神经组织的神经元一氧化氮合酶（nNOS）和caveolin-1表达。通过海绵体内压力（ICP）记录评估勃起功能。结果：与年轻对照组相比，老年大鼠的nNOS和cavoelin-1明显降低。在衰老大鼠中，维生素E和西地那非均能部分恢复nNOS的表达，但当合用时，可观察到nNOS的协同增高。西地那非可改善老年大鼠的ICP显着降低;但是，维生素E在ICP方面未产生任何其他改善。结论：老年大鼠中nNOS和小窝蛋白1的水平降低。与西地那非合用时，维生素E协同增加nNOS的表达。由于无法从生理上实现生化收益，因此可能存在其他促成因素。

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