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Preparation of Copolymer-Based Nanoparticles with Broad-Spectrum Antimicrobial Activity

机译：具有广谱抗菌活性的共聚物基纳米颗粒的制备

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摘要

Polyacrylate and guanidine-based nanoparticles which involve acrylate monomers and glycidyl methacrylate modified oligo-guanidine were prepared by a seeded semi-continuous emulsion polymerization. The results from transmission electron microscope and dynamic light scattering measurements showed that the nanoparticles were spherical in shape and the particle size was in the range of 80?￠????130 nm. Antimicrobial experiments were performed with two types of bacteria, Gram-negative ( Escherichia coli , ATCC 8739) and Gram-positive ( Staphylococcus aureus , ATCC 6538). The as-synthesized cationic nanoparticles exhibited effective antimicrobial activities on Escherichia coli and Staphylococcus aureus with the minimal inhibitory concentrations at 8 ????g/mL and 4 ????g/mL, respectively. The mechanism of action of the resulted nanoparticles against these bacteria was revealed by the scanning electron microscopic observation. In addition, the films consisting of latex nanoparticles are non-leaching antimicrobial materials with excellent antimicrobial activity, which indicates the polymers could preserve their antimicrobial activity for long-term effectiveness.
机译：通过种子半连续乳液聚合制备涉及丙烯酸酯单体和甲基丙烯酸缩水甘油酯改性的寡胍的聚丙烯酸酯和胍基纳米颗粒。透射电子显微镜和动态光散射测量的结果表明，纳米颗粒是球形的，粒径在80nm〜130nm范围内。用两种类型的细菌进行了抗菌实验，革兰氏阴性菌（大肠杆菌，ATCC 8739）和革兰氏阳性菌（金黄色葡萄球菌，ATCC 6538）。合成后的阳离子纳米颗粒对大肠杆菌和金黄色葡萄球菌表现出有效的抗菌活性，最小抑菌浓度分别为8μg/ mL和4μg/ mL。通过扫描电子显微镜观察揭示了所得纳米颗粒对抗这些细菌的作用机理。另外，由乳胶纳米颗粒组成的薄膜是具有优异抗菌活性的非浸出抗菌材料，这表明该聚合物可以保留其抗菌活性，从而具有长期有效性。

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